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Correlation of 99mTc-DMSA scan with radiological and laboratory examinations in childhood acute pyelonephritis: A time-series study

Ghasemi, K. and Montazeri, S. and Pashazadeh, A.M. and Javadi, H. and Assadi, M. (2013) Correlation of 99mTc-DMSA scan with radiological and laboratory examinations in childhood acute pyelonephritis: A time-series study. International Urology and Nephrology, 45 (4). pp. 925-932. ISSN 03011623 (ISSN)

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Background: Urinary tract infections are one of the most common diseases in children. They may lead to hypertension and renal failure later in life. Renal scintigraphy with technetium-99m dimercaptosuccinic acid (99mTc-DMSA) is one method used to diagnose acute pyelonephritis (APN) and renal parenchymal scars. The aim of the present study was to determine the ideal time to perform a follow-up 99mTc-DMSA scan to detect renal scars and also to evaluate the factors predicting the development of permanent renal damage after APN. Methods: Sixty-four children with a first episode of APN underwent a 99mTc-DMSA scan. If there were abnormal findings on this scan, another scan was performed 6 and 12 months later. Results: The baseline 99mTc-DMSA scan showed cortical changes in 35 patients (54.7 %). One the 6- and 12-month follow-up scans, 25 patients (39.06 %) and 21 patients (32.8 %), respectively, had cortical lesions. In multiple logistic regressions with the final 99mTc-DMSA scan results as the dependent variable, only the age range of the patients (β = 1.062; 95 % CI 1.014-1.113; p = 0.01) showed an independent and significant association. Gender, therapeutic delay time, ultrasonography, and voiding cystourethrogram results, as well as laboratory test results including the erythrocyte sedimentation rate, C-reactive protein level, white blood cell counts, and type of bacteria in the urine, did not show such an association (p > 0.05). Conclusion: There is not a significant difference between the results of 6- and 12-month 99mTc-DMSA follow-up scans. A follow-up 99mTc-DMSA scan should be performed 12 months after the acute scan to yield a more accurate diagnosis of permanent renal damage. If present, long-term follow-up of patients is necessary. © 2013 Springer Science+Business Media Dordrecht.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Int. Urol. Nephrol. [Field not mapped to EPrints] C2 - 23728908 [Field not mapped to EPrints] AD - Department of Paediatrics, Bushehr Medical Center Hospital, Bushehr University of Medical Sciences, Bushehr, Iran [Field not mapped to EPrints] AD - Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, 3631 Bushehr, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences (GUOMS), Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: 99mTc-DMSA scan, Acute pyelonephritis, Scar, Urinary tract infections, C reactive protein, succimer tc 99m, acute pyelonephritis, age distribution, article, bacterium identification, bacteriuria, child, child health, clinical feature, constipation, controlled study, correlational study, diagnostic accuracy, diagnostic test accuracy study, diarrhea, drug distribution, drug uptake, echography, Enterobacter, erythrocyte sedimentation rate, Escherichia coli, feeding disorder, female, follow up, gender, hematuria, human, human cell, infant, intermethod comparison, kidney cortex, kidney injury, kidney scar, kidney scintiscanning, Klebsiella, leukocyte count, major clinical study, male, micturition cystourethrography, micturition disorder, nausea and vomiting, nonhuman, predictive value, preschool child, Proteus, Pseudomonas, pyuria, school child, therapy delay, tissue distribution, urinalysis, urinary tract disease, urinary tract infection, urine culture, urine discoloration, weight gain, Acute Disease, Age Factors, Blood Sedimentation, C-Reactive Protein, Chi-Square Distribution, Child, Child, Preschool, Cohort Studies, Confidence Intervals, Disease Progression, Female, Follow-Up Studies, Humans, Infant, Logistic Models, Male, Monitoring, Physiologic, Multivariate Analysis, Prospective Studies, Pyelonephritis, Risk Assessment, Severity of Illness Index, Technetium Tc 99m Dimercaptosuccinic Acid, Time Factors, Ultrasonography, Doppler, Urinary Tract Infections
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:29
Last Modified: 23 May 2015 08:56
URI: http://eprints.goums.ac.ir/id/eprint/1847

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