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Effectiveness of methadone maintenance treatment in prevention of hepatitis C virus transmission among injecting drug users

Alavian, S.M. and Mirahmadizadeh, A. and Javanbakht, M. and Keshtkaran, A. and Heidari, A. and Mashayekhi, A. and Salimi, S. and Hadian, M. (2013) Effectiveness of methadone maintenance treatment in prevention of hepatitis C virus transmission among injecting drug users. Hepatitis Monthly, 13 (8). ISSN 1735143X (ISSN)

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Abstract

Background: Injecting drug users (IDUs) are a major and most important risk factor for rising hepatitis C virus (HCV) prevalence in Iran. Objectives: The objective of this study was to determine the effectiveness of methadone maintenance treatment (MMT) in prevention of HCV infection transmission among IDUs. Patients and Methods: A mathematical modeling has been used to estimate number of HCV infections averted. The input parameters used in the model were collected by self-reported method from 259 IDUs before registering and one year after MMT. Nonparametric statistical tests have been used to compare risky injecting and sexual behaviors among IDUs before and after participating in MMT program. Deterministic sensitivity analyses were done to show the effects of parameters' uncertainty on outcome. Results: Of the 259 participants, 98.4% (255) were men, the mean age ± SD was 33.1 ± 7.58 years and HCV prevalence was 50%. The studied IDUs reported lower rate of risky injecting and sexual behavior after participation in MMT program. The cumulative incidence of HCV per 100 IDUs due to sharing injection and unsafe sexual contact with MMT program were 13.84 (95% CI: 6.17 -21.51), 0.0003 (0.0001 - 0.0005) and without it 36.48 (25.84 - 47.11) and 0.0004 (0.0002-0.0006) respectively. Conclusions: The MMT program is an effective intervention to prevent HCV infection transmission, although it is essential to compare its effectiveness with other interventions before implementing it in nationwide. © 2013, Kowsar Corp.; Licensee Kowsar Ltd.

Item Type: Article
Additional Information: Unmapped bibliographic data: C7 - e12411 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - Hepatitis Mon. [Field not mapped to EPrints] AD - Baqiatallah Research Center for Gastrointestinal and Liver Diseases, Baqiatallah University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Middle East Liver Disease Center, Tehran, Iran [Field not mapped to EPrints] AD - HIV/AIDS Research center, Shiraz University of Medical Sciences, Shiraz, Iran [Field not mapped to EPrints] AD - Health Management and Economics Research Center, School of Health Management and Information Sciences, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Health Management and Social Development Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Health Economics, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Effectiveness, Hepatitis C, Incidence, Iran, Maintenance, Methadone, methadone, adult, article, drug abuse, female, hepatitis C, Hepatitis C virus, human, injection, Iran, major clinical study, male, mathematical model, prevalence, risk factor, self report, sensitivity analysis, sexual behavior, therapy effect, unsafe sex, virus transmission
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Apr 2015 10:02
Last Modified: 23 May 2015 07:14
URI: http://eprints.goums.ac.ir/id/eprint/1842

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