Golestan University of Medical Sciences Repository

Reproductive factors and risk of esophageal squamous cell carcinoma in northern Iran: A case-control study in a high-risk area and literature review

Islami, F. and Cao, Y. and Kamangar, F. and Nasrollahzadeh, D. and Marjani, H.-A. and Shakeri, R. and Fahimi, S. and Sotoudeh, M. and Dawsey, S.M. and Abnet, C.C. and Boffetta, P. and Malekzadeh, R. (2013) Reproductive factors and risk of esophageal squamous cell carcinoma in northern Iran: A case-control study in a high-risk area and literature review. European Journal of Cancer Prevention, 22 (5). pp. 461-466. ISSN 09598278 (ISSN)

[img]
Preview
PDF - Published Version
Download (103kB) | Preview

Abstract

Several epidemiologic studies have suggested an inverse association between female reproductive factors and the risk of esophageal squamous cell carcinoma (ESCC), but the evidence is not conclusive. We examined the association of the number of pregnancies, live births, and miscarriages/stillbirths in women and the association of the number of children in both sexes with the risk of ESCC in Golestan Province, a high-risk area in Iran. Data from 297 histopathologically confirmed ESCC cases (149 women) and 568 controls (290 women) individually matched to cases for age, sex, and neighborhood of residence were included in this analysis. Conditional logistic regression was used to calculate odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). The average numbers of live births and miscarriages/stillbirths among the controls were 8.2 and 0.8, respectively. Women with six or more live births were at �1/3 the risk of ESCC as those with 0-3 live births; the OR (95% CI) for having 6-7 live births was 0.33 (0.12-0.92). In contrast, the number of miscarriages/stillbirths was associated with an increase in the risk of ESCC. The OR (95% CI) for at least three versus no miscarriages/stillbirths was 4.43 (2.11-9.33). The number of children in women was suggestive of an inverse association with ESCC, but this association was not statistically significant; in men, no association was observed. The findings of this study support a protective influence of female hormonal factors on the risk of ESCC. However, further epidemiological and mechanistic studies are required to prove a protective association. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Eur.J. Cancer Prev. [Field not mapped to EPrints] C2 - 23238586 [Field not mapped to EPrints] AD - Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Tisch Cancer Institute, Institute for Transitional Epidemiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, United States [Field not mapped to EPrints] AD - Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States [Field not mapped to EPrints] AD - Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore, United States [Field not mapped to EPrints] AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States [Field not mapped to EPrints] AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden [Field not mapped to EPrints] AD - Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom [Field not mapped to EPrints] AD - International Prevention Research Institute, Lyon, France [Field not mapped to EPrints] AD - Research Center for Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Case-control study, Esophageal cancer, Miscarriage, Parity, Reproductive, Squamous cell carcinoma, article, cancer risk, case control study, comparative study, controlled study, disease association, esophageal squamous cell carcinoma, female, high risk population, histopathology, human, Iran, live birth, major clinical study, pregnancy, priority journal, reproductive health, spontaneous abortion, stillbirth, Abortion, Spontaneous, Carcinoma, Squamous Cell, Case-Control Studies, Esophageal Neoplasms, Female, Geography, Humans, Iran, Male, Parity, Pregnancy, Reproductive History, Risk Factors, Stillbirth
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 04:11
Last Modified: 10 May 2015 05:55
URI: http://eprints.goums.ac.ir/id/eprint/1837

Actions (login required)

View Item View Item