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Beyond the silence: Bilateral somatosensory stimulation enhances skilled movement quality and neural density in intact behaving rats

Faraji, J. and Gomez-Palacio-Schjetnan, A. and Luczak, A. and Metz, G.A. (2013) Beyond the silence: Bilateral somatosensory stimulation enhances skilled movement quality and neural density in intact behaving rats. Behavioural Brain Research, 253. pp. 78-89. ISSN 01664328 (ISSN)

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Abstract

It is thought that a close dialogue between the primary motor (M1) and somatosensory (S1) cortices is necessary for skilled motor learning. The extent of the relative S1 contribution in producing skilled reaching movements, however, is still unclear. Here we used anodal transcranial direct current stimulation (tDCS), which is able to alter polarity-specific excitability in the S1, to facilitate skilled movement in intact behaving rats. We hypothesized that the critical role of S1 in reaching performance can be enhanced by bilateral tDCS. Pretrained rats were assigned to control or stimulation conditions: (1) UnAno: the unilateral application of an anodal current to the side contralateral to the paw preferred for reaching; (2) BiAno1: bilateral anodal current; (3) BiAno2: a bilateral anodal current with additional 30. ms of 65. μA pulses every 5. s. Rats received tDCS (65. μA; 10. min/rat) to the S1 during skilled reach training for 20 days (online-effect phase). After-effect assessment occurred for the next ten days in the absence of electrical stimulation. Quantitative and qualitative analyses of online-effects of tDCS showed that UnAno and BiAno1 somatosensory stimulation significantly improve skilled reaching performance. Bilateral BiAno1 stimulation was associated with greater qualitative functional improvement than unilateral UnAno stimulation. tDCS-induced improvements were not observed in the after-effects phase. Quantitative cytoarchitectonic analysis revealed that somatosensory tDCS bilaterally increases cortical neural density. The findings emphasize the central role of bilateral somatosensory feedback in skill acquisition through modulation of cortico-motor excitability. © 2013 Elsevier B.V.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Behav. Brain Res. [Field not mapped to EPrints] C2 - 23871611 [Field not mapped to EPrints] AD - Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada [Field not mapped to EPrints] AD - Golestan University of Medical Sciences, P.O. Box 49165-568, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Motor cortex, Skilled movement, Skilled reaching behavior, Somatosensory cortex, TDCS, adult animal, analysis, animal experiment, animal tissue, article, brain cortex, controlled study, cortical neural density, cortical thickness, cytoarchitectonic analysis, electric current, feedback system, learning, male, nerve cell excitability, nervous system parameters, nonhuman, performance, priority journal, rat, skill, skilled motor learning, somatosensory cortex, somatosensory stimulation, thickness, transcranial direct current stimulation, Motor cortex, Skilled movement, Skilled reaching behavior, Somatosensory cortex, tDCS, Animals, Behavior, Animal, Biomechanical Phenomena, Cell Count, Electric Stimulation, Electrodes, Functional Laterality, Male, Motor Cortex, Motor Skills, Neurons, Psychomotor Performance, Rats, Rats, Long-Evans, Somatosensory Cortex, Stereotaxic Techniques
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 10:02
Last Modified: 10 May 2015 04:51
URI: http://eprints.goums.ac.ir/id/eprint/1833

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