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Normal limit for serum alanine aminotransferase level and distribution of metabolic factors in old population of Kalaleh, Iran

Kabir, A. and Pourshams, A. and Khoshnia, M. and Malekzadeh, F. (2013) Normal limit for serum alanine aminotransferase level and distribution of metabolic factors in old population of Kalaleh, Iran. Hepatitis Monthly, 13 (10). ISSN 1735143X (ISSN)

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Abstract

Backgrounds: Normal or elevated values of serum alanine aminotransferase level (ALT) vary in different studies mostly related to characteristics of reference population including age, gender, body mass index, nonalcoholic fatty liver disease (NAFLD), and metabolic syndrome prevalence. Objectives: To measure upper normal limit (UNL) for serum ALT in an apparently healthy Iranian old population (which we had not sufficient data before this study), and its modulating factors. Patients and Methods: All inhabitants (> 50 years old) of Kalaleh, Golestan, Iran (N = 1986) were invited to the study. ALT measurements were performed for all subjects using the same laboratory method. Upper limit of normal (ULN) ALT was calculated based on its 95th percentile in normal weight subjects. Modulating factors of ALT were determined by multivariate analysis. Results: A total of 1309 subjects, with the mean age of 61.5 ± 7.5 years were included. UNL of ALT was 18.8 U/L and 21.4 U/L in women and men, respectively. Based on univariate analysis, waist circumference (r = 0.124, P = 0.01), body mass index (r = 0.118, P = 0.01), triglyceride (r = 0.143, P = 0.01), and having metabolic syndrome (OR = 2.04) modulate ALT levels in men. Also triglyceride (r = 0.119, P = 0.01) modulates ALT levels in women. Conclusions: The calculated level for UNL of ALT is considerably far lower than previous accepted value. Age, gender, ethnicity, and metabolic factors should be accounted in future studies to determine normal ALT level. © 2013, Kowsar Corp.; Published by Kowsar Corp.

Item Type: Article
Additional Information: Unmapped bibliographic data: C7 - e10640 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - Hepatitis Mon. [Field not mapped to EPrints] AD - Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Center for Educational Research in Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Age groups, Alanine aminotransferase, Gender, alanine aminotransferase, aspartate aminotransferase, cholesterol, high density lipoprotein, low density lipoprotein, triacylglycerol, adult, age, aged, article, blood pressure monitoring, body mass, ethnicity, female, gender, human, Iran, limit of quantitation, major clinical study, male, metabolic parameters, metabolic regulation, metabolic syndrome X, multivariate analysis, obesity, upper normal limit, waist circumference
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Apr 2015 09:50
Last Modified: 10 May 2015 07:08
URI: http://eprints.goums.ac.ir/id/eprint/1819

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