Golestan University of Medical Sciences Repository

Epidemiology of Helicobacter pylori infection among Iranian children

Ghasemi-Kebria, F. and Ghaemi, E. and Azadfar, S. and Roshandel, G. (2013) Epidemiology of Helicobacter pylori infection among Iranian children. Arab Journal of Gastroenterology, 14 (4). pp. 169-172. ISSN 16871979 (ISSN)

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Abstract

Background and study aims: Infection with Helicobacter pylori (HP) either in children or in adults is a risk factor for gastric cancer. The Golestan province located in northeast Iran has been known to be a high-risk area for oesophageal and gastric cancers. This study was conducted to assess the epidemiology of this infection in the children of Golestan. Patients and methods: This study was carried out in 2009 on healthy children (1-15. years) of the Golestan province. Serum immunoglobulin G (Ig G) antibody against HP was tested in these children and positive samples were tested for anti-cytotoxin-associated antigen A (anti-CagA) antibody. To assess the relationship between HP infection and the risk of gastric cancer, the Golestan province was divided into high- and low-risk areas based on the incidence rate of gastric cancer. The chi-squared test was used to assess the relationship between variables. Results: Totally, 194 subjects were recruited. The prevalence of HP infection in our area was 50.5%. The prevalence of HP infection was significantly higher in the high-risk than in the low-risk area for stomach cancer (p=0.004). The seropositivities of HP (p=0.03) and CagA (p=0.04) were significantly lower in children <5. years than in others. Conclusion: Our results showed a high prevalence of HP infection in children of the Golestan province of Iran. We also found a significant positive relationship between childhood HP infection and the risk of gastric cancer. Hence, childhood HP infection may be considered a possible determinant of gastric cancer in this high-risk area. Implementation of preventive programmes may help to reduce the burden of childhood HP infection and, consequently, gastric cancer in this area. © 2013 Arab Journal of Gastroenterology.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Arab J. Gastroenterol. [Field not mapped to EPrints] C2 - 24433647 [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Microbiology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Children, Gastric malignancy, Golestan, Helicobacter pylori, Iran, antibody, cytotoxin associated antigen A antibody, immunoglobulin G antibody, unclassified drug, adolescent, antibody blood level, article, blood sampling, cancer risk, child, childhood disease, enzyme linked immunosorbent assay, epidemiology, ethnicity, female, Helicobacter infection, human, major clinical study, male, preschool child, priority journal, school child, stomach cancer, Children, Gastric malignancy, Golestan, Helicobacter pylori, Iran, Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Female, Helicobacter Infections, Helicobacter pylori, Humans, Incidence, Infant, Iran, Male, Prevalence, Risk Factors, Stomach Neoplasms
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 08:58
Last Modified: 23 May 2015 09:31
URI: http://eprints.goums.ac.ir/id/eprint/1817

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