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Genotyping of Echinococcus granulosus from domestic animals and humans from Ardabil Province, northwest Iran

Pezeshki, A. and Akhlaghi, L. and Sharbatkhori, M. and Razmjou, E. and Oormazdi, H. and Mohebali, M. and Meamar, A.R. (2013) Genotyping of Echinococcus granulosus from domestic animals and humans from Ardabil Province, northwest Iran. Journal of Helminthology, 87 (4). pp. 387-391. ISSN 0022149X (ISSN)

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Abstract

Cystic echinococcosis is endemic in Iran, particularly in Ardabil Province, where it causes health and economic problems. The genetic pattern of Echinococcus granulosus has been determined in most parts of Iran, except in this area. In the present investigation, 55 larval isolates were collected from humans (11), sheep (19), goats (4) and cattle (21). For analysis of the genetic characteristics of E. granulosus isolates, DNA sequencing of mitochondrial cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 1 (nad1) genes was applied. Fifty isolates were successfully analysed, with 92% (46) and 8% (4) identified as G1 and G3 genotypes, respectively. The sequence analyses of the isolates displayed nine characteristic profiles in cox1 sequences and eight characteristic profiles in nad1 sequences. Based on these results, the sheep strain (G1 genotype) was the most prevalent in humans, sheep, goats and cattle. The buffalo strain (G3 genotype) was not only demonstrated in sheep (1 isolate) and cattle (1 isolate), but also for the first time in two human isolates. These findings will provide information for local control of echinococcosis. © Cambridge University Press 2012.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Helminthol. [Field not mapped to EPrints] C2 - 23046636 [Field not mapped to EPrints] AD - Department of Parasitology and Mycology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran [Field not mapped to EPrints] AD - Laboratory Science Research Center, Golestan, University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Parasitology and Mycology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: cytochrome c oxidase, reduced nicotinamide adenine dinucleotide dehydrogenase, cytochrome c oxidase, cytochrome c oxidase subunit 1, DNA, NADH dehydrogenase subunit 1, reduced nicotinamide adenine dinucleotide dehydrogenase, unclassified drug, amplicon, article, clinical article, DNA sequence, domestic animal, echinococcosis, Echinococcus granulosus, gene cluster, genetics, genotype, haplotype, human, infection control, Iran, larva, nonhuman, nucleotide sequence, animal experiment, Article, buffalo, cattle, controlled study, domestic animal, gene expression, gene identification, genetic analysis, genetic trait, genetic variability, goat, mitochondrion, nucleotide sequence, parasite prevalence, population genetic structure, sheep, Animals, Animals, Domestic, Cattle, Cluster Analysis, DNA, Helminth, Echinococcosis, Echinococcus granulosus, Electron Transport Complex IV, Genetic Variation, Genotype, Humans, Iran, Larva, Molecular Sequence Data, NADH Dehydrogenase, Phylogeny, Sequence Analysis, DNA
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 04:03
Last Modified: 20 Jun 2015 07:46
URI: http://eprints.goums.ac.ir/id/eprint/1813

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