Golestan University of Medical Sciences Repository

No evidence of association between CTLA-4 polymorphisms and systemic lupus erythematosus in Iranian patients

Shojaa, M. and Javid, N. and Amoli, M. and Shakeri, F. and Samaei, N.M. and Aghaie, M. and Khashayar, P. and Livani, S. (2013) No evidence of association between CTLA-4 polymorphisms and systemic lupus erythematosus in Iranian patients. International Journal of Rheumatic Diseases, 16 (6). pp. 681-684. ISSN 17561841 (ISSN)

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Abstract

Aim: Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an important negative regulator of T-cell responses. CTLA-4 polymorphisms have been confirmed to be associated with several autoimmune diseases such as systemic lupus erythematosus (SLE). We analyzed the role of CTLA-4 polymorphism at positions -1661 and -1722 in Iranian patients suffering from SLE. Methods: One hundred and eighty SLE patients and 304 ethnically and age-matched healthy controls were studied. Polymerase chain reaction restriction fragments length polymorphism (PCR-RFLP) was used to analyze the genotype and allele frequencies of these polymorphisms. Results: There was no significant association between the studied genotypic and allelic frequencies between SLE patients and the controls. Although the TC genotype in 1722TC polymorphism was more common among the control group, the correlation was not statistically significant. Conclusion: Our results suggest that the -1661AG and -1722TC polymorphisms in the promoter region of the CTLA-4 gene does not play any role in genetic susceptibility to SLE. However, further studies on larger sample sizes are needed to approve our results. © 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Int. J. Rheum. Dis. [Field not mapped to EPrints] C2 - 24382279 [Field not mapped to EPrints] AD - Protection Unit of Clinical Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Faculty of Medicine, Department of Microbiology, Infection Disease Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Microbiology, Payam Noor University of Golestan, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Genetics, Congenital Malformations Research Center, OMICS Research Center, Hematology and Oncology Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Faculty of Medicine, Department of Rheumatology, Bone Joint and Connective Tissue Research Center (BJCRC), Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: CTLA-4, Polymorphism, Promoter, Systemic lupus erythematosus, cytotoxic T lymphocyte antigen 4, adolescent, adult, aged, article, controlled study, disease association, DNA polymorphism, female, gene frequency, gene linkage disequilibrium, genotype, haplotype, human, Iran, major clinical study, male, middle aged, polymerase chain reaction, priority journal, promoter region, restriction fragment length polymorphism, systemic lupus erythematosus, young adult, CTLA-4, polymorphism, promoter, systemic lupus erythematosus, Adolescent, Adult, Aged, Asian Continental Ancestry Group, Case-Control Studies, CTLA-4 Antigen, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Iran, Lupus Erythematosus, Systemic, Male, Middle Aged, Phenotype, Polymerase Chain Reaction, Polymorphism, Genetic, Promoter Regions, Genetic, Risk Factors, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:26
Last Modified: 11 May 2015 04:51
URI: http://eprints.goums.ac.ir/id/eprint/1812

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