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Breast cancer risk in opposite-sexed twins: Influence of birth weight and co-twin birth weight

Hajiebrahimi, M. and Bahmanyar, S. and Oberg, S. and Iliadou, A.N. and Cnattingius, S. (2013) Breast cancer risk in opposite-sexed twins: Influence of birth weight and co-twin birth weight. Journal of the National Cancer Institute, 105 (23). pp. 1833-1836. ISSN 00278874 (ISSN)

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Abstract

Most, but not all, studies report a positive association between birth weight, as an indirect marker of prenatal hormone exposure, and offspring breast cancer risk, particularly premenopausal breast cancer. Females from opposite-sexed twin pairs may also be prenatally exposed to androgens from their twin brothers. A Swedish study of opposite-sexed twins with a small sample size found a very strong positive association between female birth weight and breast cancer risk. In this case-control study, nested within a cohort of female opposite-sexed twins, we included 543 breast cancer case subjects diagnosed in the period from 1972 to 2008 and 2715 matched control subjects. Conditional logistic regression estimated the breast cancer risk associated with birth weight and other birth characteristics, including gestational age and co-twin birth weight. All statistical tests were two-sided. There was no association between birth weight (odds ratio = 1.01; 95% confidence interval = 0.70 to 1.46) or twin brother's birth weight and risk of breast cancer, which suggests the previously reported strong positive association may have been a chance finding. © The Author 2013.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Natl. Cancer Inst. [Field not mapped to EPrints] C2 - 24231452 [Field not mapped to EPrints] AD - Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, SE-171 76 Stockholm, Sweden [Field not mapped to EPrints] AD - Center for Pharmacoepidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] AD - Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States [Field not mapped to EPrints] AD - Faculty of Public Health, Golestan University of Medical Sciences, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: androgen, hormone, marker, adult, article, birth weight, breast cancer, cancer risk, case control study, controlled study, gestational age, human, major clinical study, priority journal, progeny, sample size, twins, Adult, Birth Weight, Breast Neoplasms, Case-Control Studies, Diseases in Twins, Female, Humans, Infant, Newborn, Logistic Models, Male, Middle Aged, Odds Ratio, Pregnancy, Prenatal Exposure Delayed Effects, Risk, Risk Factors, Sex Factors, Sweden
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 04:42
Last Modified: 10 May 2015 05:27
URI: http://eprints.goums.ac.ir/id/eprint/1804

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