Sedighi, S. and Aghaei, M. and Musavi, S. and Nomali, M. (2014) Relationship between serum level of interleukin-2 in patients with systemic lupus erythematosus and disease activity in comparison with control group. Journal of Clinical and Diagnostic Research, 8 (7). MC16-MC18. ISSN 2249782X (ISSN)
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Abstract
Background: Despite the large number of surveys, there are not any validated biomarkers for SLE disease activity till now. This study aimed to evaluate the relationship between serum level of IL-2 in patients with SLE and disease activity in comparison with control group. Materials and Methods: In this case-control study, 73 patients with lupus and 73 healthy subjects referred to the rheumatology clinic of 5 Azar Hospital in Gorgan (North of Iran).They were studied via convenience sampling during 2011-2012. Blood samples were taken from both groups and serum levels of interleukin -2 measured by Avi Bion Human IL-2 ELISA kit. Serum Level of IL-2 greater than 15 pg/ml defined positive and lesser than this amount defined negative. Disease activity evaluated with SLE disease activity index. Score greater than or equal to three or four defined as active disease. Data analysis conducted by SPSS software (version 16) and by using descriptive statistics and statistical tests. Results: Serum level of IL-2 was positive in 45.2% of sample studied and negative in 54.8% in case group, while in control group, serum level of IL-2 only in 11% of sample studied was positive and in 89% was negative. Statistical analysis indicated a significant relationship between serum level of IL-2 and the SLE disease activity index (p=0.025). Conclusion: This study showed the relationship between serum levels of IL-2 and disease activity, so this biomarker can be used as a clinical indicator for assessing disease activity in patients with SLE.
| Item Type: | Article |
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| Additional Information: | Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Clin. Diagn. Res. [Field not mapped to EPrints] AD - Bone and Connective Tissue Research Centre (JBCRC), Golesatan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Clinical Research Development Unit (CRDU), 5 Azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints] |
| Uncontrolled Keywords: | Adults, Disease activity, ELISA, Interleukin-2, Systematic lupus erythematosus, azathioprine, hydroxychloroquine sulfate, interleukin 2, methotrexate, prednisone, adult, article, case control study, comparative study, controlled study, disease activity, disease activity score, enzyme linked immunosorbent assay, female, human, major clinical study, male, systemic lupus erythematosus |
| Subjects: | مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus موارد کلی |
| Divisions: | معاونت تحقیقات و فناوری |
| Depositing User: | GOUMS |
| Date Deposited: | 18 Apr 2015 08:05 |
| Last Modified: | 09 May 2015 05:39 |
| URI: | http://eprints.goums.ac.ir/id/eprint/1782 |
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