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Attenuation of hemodynamic responses to laryngoscopy and tracheal intubation: Propacetamol versus lidocaine - A randomized clinical trial

Kord Valeshabad, A. and Nabavian, O. and Nourijelyani, K. and Kord, H. and Vafainejad, H. and Kord Valeshabad, R. and Reza Feili, A. and Rezaei, M. and Darabi, H. and Koohkan, M. and Golbinimofrad, P. and Jafari, S. (2014) Attenuation of hemodynamic responses to laryngoscopy and tracheal intubation: Propacetamol versus lidocaine - A randomized clinical trial. Anesthesiology Research and Practice, 2014. ISSN 16876962 (ISSN)

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Abstract

The purpose of this study is to assess the effects of propacetamol on attenuating hemodynamic responses subsequent laryngoscopy and tracheal intubation compared to lidocaine. In this randomized clinical trial, 62 patients with the American Anesthesiologists Society (ASA) class I/II who required laryngoscopy and tracheal intubation for elective surgery were assigned to receive propacetamol 2 g/I.V./infusion (group P) or lidocaine 1.5 mg/kg (group L) prior to laryngoscopy. Systolic and diastolic blood pressures (SBP, DBP), mean arterial pressure (MAP), and heart rate (HR) were recorded at baseline, before laryngoscopy and within nine minutes after intubation. In both groups P and L, MAP increased after laryngoscopy and the changes were statistically significant (P < 0.001). There were significant changes of HR in both groups after intubation (P < 0.02), but the trend of changes was different between two groups (P < 0.001). In group L, HR increased after intubation and its change was statistically significant within 9 minutes after intubation (P < 0.001), while in group P, HR remained stable after intubation (P = 0.8). Propacetamol 2 gr one hour prior intubation attenuates heart rate responses after laryngoscopy but is not effective to prevent acute alterations in blood pressure after intubation. © 2014 Ali Kord Valeshabad et al.

Item Type: Article
Additional Information: Unmapped bibliographic data: C7 - 170247 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - Anesthesiology Res. Pract. [Field not mapped to EPrints] AD - Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, IL 60612, United States [Field not mapped to EPrints] AD - Department of Anaesthesiology, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, Iran [Field not mapped to EPrints] AD - Department of Epidemiology of Biostatistics, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, Iran [Field not mapped to EPrints] AD - Department of Dermatology, Golestan University of Medical Sciences, Gorgan 4934174515, Iran [Field not mapped to EPrints] AD - Zainaldin Martyr Research Center, Gorgan University of Agricultural Sciences and Natural Resources, P.O. Box 15739-49138, Gorgan, Iran [Field not mapped to EPrints] AD - Center for Cardiovascular Research, University of Illinois at Chicago, 835 S. Wolcott Avenue, Chicago, IL 60612, United States [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: lidocaine, propacetamol, adult, article, comparative study, controlled study, diastolic blood pressure, drug effect, elective surgery, endotracheal intubation, female, heart rate, hemodynamics, human, hypertension, hypotension, laryngoscopy, major clinical study, male, mean arterial pressure, randomized controlled trial, systolic blood pressure, tachycardia
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Apr 2015 09:36
Last Modified: 05 May 2015 04:43
URI: http://eprints.goums.ac.ir/id/eprint/1781

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