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Benefits of using intrathecal buprenorphine

Rabiee, S.M. and Alijanpour, E. and Jabbari, A. and Rostami, S. (2014) Benefits of using intrathecal buprenorphine. Caspian Journal of Internal Medicine, 5 (3). pp. 143-147. ISSN 20086164 (ISSN)

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Abstract

Background: General anesthesia draws attention to the most commonly used modalities for post cesarean delivery pain relief in systemic administration of opioids, while the administration of small dose of intrathecal opioid during spinal anesthesia can be a possible alternative. The aim of this study was to evaluate the effects of buprenorphine on cesarean section prescribed intrathecally. Methods: This double blind randomized clinical trial study was conducted in patients for cesarean section under spinal anesthesia. The patients were randomly divided into case and control groups. Case group (208 patients) received 65-70 mg of 5% lidocaine plus 0.2 ml of buprenorphine while the same amount of 5% lidocaine diluted with 0.2 ml of normal saline was given to 234 cases in the control group. Hemodynamic changes and neonatal APGAR scores (Appearance, Pulse, Grimace, Activity, Respiration) were recorded. Pain score was recorded according to the visual analog scale. This study was registered in the Iranian Registry of clinical Trials; IRCT2013022112552N1. Results: The mean age of case and control groups was 24.4±5.38 and 26.84±5.42 years, respectively. Systolic blood pressure was not significantly different until the 45th minute but diastolic blood pressure showed a significant difference at the 15th and the 60th minutes (P<0.001). Heart rate changes were significantly different between cases and controls at the initial 5th, 15th and after 60th minutes (P<0.001). Pain-free period was significantly different between two groups (1.25 h versus 18.73 h) (P<0.001). Conclusion: The results show that prescription of intratechal buprenorphine prolongs the duration of analgesia without any significant considerable side effects.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Caspian J. Int. Med. [Field not mapped to EPrints] AD - Department of Anesthesiology and Intensive Care, Babol University of Medical Sciences, Babol, Iran [Field not mapped to EPrints] AD - Department of Anesthesiology and Intensive Care, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Babol University of Medical Sciences, Babol, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Buprenorphine, Intrathecal, Pain, Post operation, Spinal anesthesia, buprenorphine, lidocaine, adolescent, adult, adverse outcome, age, analgesia, Apgar score, apnea, article, cesarean section, clinical effectiveness, clinical evaluation, controlled study, diastolic blood pressure, double blind procedure, drug efficacy, drug safety, female, heart rate, hemodynamic monitoring, human, major clinical study, nausea, pain assessment, prescription, pruritus, randomized controlled trial, spinal anesthesia, systolic blood pressure, treatment duration, visual analog scale, vomiting
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 10:16
Last Modified: 09 May 2015 04:32
URI: http://eprints.goums.ac.ir/id/eprint/1773

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