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Cost-effectiveness of Methadone Maintenance Treatment in prevention of HIV among drug users in Shiraz, south of Iran

Keshtkaran, A. and Mirahmadizadeh, A. and Heidari, A. and Javanbakht, M. (2014) Cost-effectiveness of Methadone Maintenance Treatment in prevention of HIV among drug users in Shiraz, south of Iran. Iranian Red Crescent Medical Journal, 16 (1). ISSN 20741804 (ISSN)

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Abstract

Background: The increase in high-risk injections and unsafe sexual behaviors has led to increased HIV infection prevalence among Intravenous Drug Users (IDUs). The high costs of HIV/AIDS care and low financial resources necessitate an economic evaluation to make the best decision for the control of HIV/AIDS. Objectives: This study was conducted to determine the cost-effectiveness of Methadone Maintenance Treatment (MMT) centers in HIV infection prevention among drug users. Materials and Methods: In this interventional study, we included all the seven MMT centers and the drug users registered there (n = 694). We calculated all the costs imposed on the government, i.e. Provider of case. Mathematical models were used to estimate the number of HIV cases averted from high-risk behaviors. Sensitivity analyses were performed to show the effects of uncertainty in parameters on the number of HIV cases averted and also Incremental Cost-Effectiveness Ratio (ICER). Results: Based on the averted models, the selected MMT centers could prevent 128 HIV cases during 1 year. The total cost was $ 547423 and that of HIV/AIDS care in the no intervention scenario was estimated $ 14171816. ICER was $ 106382 per HIV case averted. The results of the sensitivity analysis indicated that MMT intervention was cost-effective even in the worst scenario and ICER varied from $ 39149 to $ 290004 per HIV case averted. Conclusions: With regard to the high prevalence of drug injection among drug users and considering the high effectiveness and cost-effectiveness of MMT centers in preventing HIV infection, establishment of MMT centers in regional and national levels seems reasonable. © 2013, Iranian Red Crescent Medical Journal.

Item Type: Article
Additional Information: Unmapped bibliographic data: C7 - e7801 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - Iran. Red Crescent Med.J. [Field not mapped to EPrints] AD - School of Management and Medical Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran [Field not mapped to EPrints] AD - Shiraz AIDS Research Center, Shiraz University of Medical Sciences, Shiraz, Iran [Field not mapped to EPrints] AD - Health Management and Social Development Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Health Economics Research Unit, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Cost-benefit analysis, HIV, Maintenance, Methadone, Therapeutics, methadone, acquired immune deficiency syndrome, adolescent, adult, aged, article, cost effectiveness analysis, female, health care financing, high risk behavior, hospital running cost, human, Human immunodeficiency virus infection, Human immunodeficiency virus prevalence, infection risk, Iran, major clinical study, male, methadone treatment, middle aged, nursing cost, sensitivity analysis, sexual transmission, unsafe sex, young adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 08:58
Last Modified: 05 May 2015 04:30
URI: http://eprints.goums.ac.ir/id/eprint/1769

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