Golestan University of Medical Sciences Repository

Emergence of a new focus of visceral leishmaniasis due to Leishmania infantum in Golestan Province, north-eastern of Iran

Fakhar, M. and Asadi Kia, A. and Gohardehi, S. and Sharif, M. and Mohebali, M. and Akhoundi, B. and Pagheh, A. and Dadimoghadam, Y. and Cheraghali, F. (2014) Emergence of a new focus of visceral leishmaniasis due to Leishmania infantum in Golestan Province, north-eastern of Iran. Journal of Parasitic Diseases, 38 (3). pp. 255-259. ISSN 09717196 (ISSN)

[img]
Preview
PDF - Published Version
Download (255kB) | Preview

Abstract

Over the last decade, a few cases of visceral leishmaniasis (VL) have been reported in some districts of the province of Golestan, in north-eastern Iran. The aim of the present study was to investigate the prevalence of Leishmania infantum infection among humans and domestic dogs by using direct agglutination test (DAT) and PCR assays in the eastern zone of the province. Between 2011 and 2012, blood samples were randomly collected from 450 humans and 50 domestic dogs, in the eastern zone of Golestan Province including 7 villages from Marave-tappeh district where new cases of human VL had been recorded there. Each of these samples was tested for anti-Leishmania antibodies, in DAT, and for L. infantum kinetoplast DNA on whole blood, in PCR-based assays. A total of 450 human samples, 6 (1.33 %) were found seropositive and 13 (2.8 %) was found PCR-positive. Of the 50 dog samples, 16 (32 %) were found seropositive and 15 (30 %) were PCR-positive. All PCR-positive dogs were found seropositive except one as well as 6 (46.2 %) PCR-positive humans were also found seropositive. Moreover, the species of L. infantum was detected in all PCR-positive samples. The high prevalence of VL in the study areas offer it has emerged as an endemic focus in the province. Further investigations on the vectors, reservoirs and human population are recommended. © 2013 Indian Society for Parasitology.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Parasitic Dis. [Field not mapped to EPrints] AD - Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, P.O. Box 48175-1665, Sari, Iran [Field not mapped to EPrints] AD - Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran [Field not mapped to EPrints] AD - Center for Research of Endemic Parasites of Iran (CREPI), Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Pediatric Ward, Taleghani Hospital, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Parasitology and Mycology, School of Medicine, Km 18, Khazar-Abad Road, P.O. Box 48175-1665, Sari, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Emergence, Endemic focus, Iran, Leishmania infantum, Zoonotic visceral leishmaniasis, kinetoplast DNA, agar gel electrophoresis, agglutination test, alopecia, article, child, controlled study, DNA sequence, dog, female, fever, hepatosplenomegaly, human, Iran, Leishmania infantum, male, nonhuman, parasite prevalence, polymerase chain reaction, preschool child, priority journal, school child, skin defect, visceral leishmaniasis, weight reduction
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 04:56
Last Modified: 04 May 2015 09:36
URI: http://eprints.goums.ac.ir/id/eprint/1766

Actions (login required)

View Item View Item