Golestan University of Medical Sciences Repository

Impact of body size and physical activity during adolescence and adult life on overall and cause-specific mortality in a large cohort study from Iran

Etemadi, A. and Abnet, C.C. and Kamangar, F. and Islami, F. and Khademi, H. and Pourshams, A. and Poustchi, H. and Bagheri, M. and Sohrabpour, A.A. and Aliasgar, A. and Khoshnia, M. and Wacholder, S. and Matthews, C.C. and Pharoah, P.D. and Brennan, P. and Boffetta, P. and Malekzadeh, R. and Dawsey, S.M. (2014) Impact of body size and physical activity during adolescence and adult life on overall and cause-specific mortality in a large cohort study from Iran. European Journal of Epidemiology, 29 (2). pp. 95-109. ISSN 03932990 (ISSN)

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We conducted this study to examine life-course body size and physical activity in relation to total and cause-specific mortality, which has not previously been studied in the low and middle-income countries in Asia. The Golestan Cohort Study is a population-based cohort in northeastern Iran in which 50,045 people above the age of 40 have been followed since 2004. Participants were shown a validated pictogram to assess body size at ages 15, 30, and the time of recruitment. Information on occupational physical activity at these ages was also collected. Subjects were followed up annually, and cause of death was determined. Cox regression models were adjusted for age at cohort start, smoking, socioeconomic status, ethnicity, place of residence, education, and opium use. Models for body size were also adjusted for physical activity at the same age, and vice versa. During a total of 252,740 person-years of follow-up (mean follow-up duration 5.1 ± 1.3 years) through December 2011, 2,529 of the cohort participants died. Larger body sizes at ages 15 or 30 in both sexes were associated with increased overall mortality. Cancer mortality was more strongly associated with adolescent obesity, and cardiovascular mortality with early adulthood body size. Weight gain between these ages was associated with cardiovascular mortality. Obese adolescents who lost weight still had increased mortality from all medical causes in both sexes. Physical activity during adolescence and early adulthood had no association with mortality, but at cohort baseline higher levels of activity were associated with reduced mortality. Mortality in this Middle-Eastern population was associated with obesity both during adolescence and early adult life. © 2014 Springer Science+Business Media.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Eur. J. Epidemiol. [Field not mapped to EPrints] C2 - 24557643 [Field not mapped to EPrints] AD - Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, United States [Field not mapped to EPrints] AD - Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore, MD, United States [Field not mapped to EPrints] AD - International Agency for Research on Cancer, Lyon, France [Field not mapped to EPrints] AD - Tisch Cancer Institute, Institute for Translational Epidemiology, Mount Sinai School of Medicine, New York, NY, United States [Field not mapped to EPrints] AD - Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Departments of Oncology and Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom [Field not mapped to EPrints] AD - International Prevention Research Institute, Lyon, France [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Adolescence, Cancer, Cardiovascular disease, Mortality, Obesity, Physical activity, opiate, adolescence, adolescent, adult, adulthood, article, body mass, body size, cancer mortality, cardiovascular disease, cardiovascular mortality, cause of death, cohort analysis, controlled study, disease association, education, ethnicity, female, follow up, human, Iran, major clinical study, male, malignant neoplastic disease, middle aged, Middle East, mortality, obesity, physical activity, smoking, social status, waist circumference, weight gain, weight reduction, Adolescent, Adult, Body Mass Index, Body Size, Cardiovascular Diseases, Cause of Death, Cohort Studies, Female, Health Surveys, Humans, Iran, Male, Mortality, Motor Activity, Neoplasms, Obesity, Population Surveillance, Proportional Hazards Models, Risk Factors, Social Class, Socioeconomic Factors, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 04:04
Last Modified: 19 May 2015 04:14
URI: http://eprints.goums.ac.ir/id/eprint/1758

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