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Ethnical variations in the incidence of congenital heart defects in Gorgan, Northern Iran: A single-center study

Nikyar, B. and Sedehi, M. and Qorbani, M. and Nikyar, A. and Golalipour, M.J. (2014) Ethnical variations in the incidence of congenital heart defects in Gorgan, Northern Iran: A single-center study. Journal of Tehran University Heart Center, 9 (1). pp. 9-14. ISSN 17358620 (ISSN)

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Background: Congenital heart disease (CHD) is the most common congenital anomaly in newborns. This study was performed to determine the live birth incidence of CHD by ethnicity and sex in Gorgan, Northern Iran. Methods: In this longitudinal, hospital-based study, 18162 live births in Dezyani Hospital in Gorgan, North of Iran, were screened for CHD, from 2007 through 2009. Clinical examination, echocardiography, color Doppler, and cardio catheterization were used as diagnostic tools. Sex, ethnicity, and type of CHD for each case were recorded in a pre-designed questionnaire. Results: The incidence rates of CHD in the native Fars, Sistani, and Turkmen subjects were 5.73 (95%CI: 4.53-7.15), 12.27 (95%CI: 8.74-16.73), and 15.93 (95%CI: 10.00-24.02) per 1000 live births, respectively. The Turkmen to native Fars and Sistani to native Fars relative risk for congenital CHD malformations was 2.77 (95%CI: 1.73-4.44; p value < 0.001) and 1.29 (95%CI: 0.77-2.18; p value < 0.323), respectively. While atrial septal defect was the most common lesion in the native Fars subjects (2.14 per 1000 [95%CI: 1.42-3.06]) and in the Sistani subjects (2.84 per 1000 [95%CI: 1.29-5.36]), in the Turkmen subjects, ventricular septal defect (4.36 per 1000 [95%CI: 1.59-9.43]), followed by atrial septal defect, was the most frequent lesion. Conclusion: This study showed that the incidence and pattern of CHD among live births in Gorgan, North of Iran, varied according to ethnicity. The risk of CHD was higher in the Turkmen and Sistani groups than in the Fars population.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Tehran. Uni. Heart. Cent. [Field not mapped to EPrints] AD - Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Public Health, Alborz University of Medical Sciences, Karaj, Iran [Field not mapped to EPrints] AD - Non-Communicable Diseases Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Cranfield University, London, United Kingdom [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Atrial, Congenital, Ethnic group, Heart defect, Heart septal defect, Incidence, Ventricular, aorta coarctation, article, clinical examination, color ultrasound flowmetry, congenital heart malformation, Ebstein anomaly, echocardiography, ethnic difference, ethnicity, Fallot tetralogy, female, great vessels transposition, heart atrium septum defect, heart catheterization, heart ventricle septum defect, hospital, human, Iran, live birth, longitudinal study, major clinical study, male, mitral valve prolapse, mitral valve regurgitation, morbidity, newborn, patent ductus arteriosus, patent foramen ovale, pericardial effusion, pulmonary hypertension, pulmonary valve insufficiency, pulmonary valve stenosis, questionnaire, screening, tricuspid valve regurgitation
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:12
Last Modified: 09 May 2015 04:17
URI: http://eprints.goums.ac.ir/id/eprint/1756

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