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Early post-operative relief of pain and shivering using diclofenac suppository versus intravenous pethidine in spinal anesthesia

Ebrahim, A.J. and Mozaffar, R. and Nadia, B.-H. and Ali, J. (2014) Early post-operative relief of pain and shivering using diclofenac suppository versus intravenous pethidine in spinal anesthesia. Journal of Anaesthesiology Clinical Pharmacology, 30 (2). pp. 243-247. ISSN 09709185 (ISSN)

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Abstract

Background: Pain and shivering are two challenging components in the post operative period. Many drugs were used for prevention and treatment of them. The aim of this study was to compare the effects of prophylactic prescription of diclofenac suppository versus intravenous (IV) pethidine in spinal anesthesia. Materials and Methods: We conducted a multi central, prospective, double-blind, randomized clinical trial on a total of 180 patients who were scheduled for surgery under spinal anesthesia including 60 patients in three groups. Patients were randomly allocated to receive 100 mg sodium diclofenac suppository or 30 mg IV pethidine or placebo. Categorical and continuous variables were analyzed by Chi-square test, t-test, Mann-Whitney and ANOVA or Kruskal-Wallis tests. Results: There was no statistical difference with regard to patient characteristics and hemodynamic indices among the three groups. Nine (15%), 10 (16.65%) and 24 (40%) of patients in diclofenac, pethidine and control groups reported pain and 2, 2, 7 patients received treatment due to it, respectively (P = 0.01). Prevalence of shivering in pethidine group and diclofenac group was the same and both of them were different from the control group (P < 0.001). Pruritus was repetitive in the pethidine group and was statistically significant (P = 0.036) but, post-operative nausea and vomiting was not significantly different among groups. Conclusion: A single dose of sodium diclofenac suppository can provide satisfactory analgesia immediately after surgery and decrease shivering without remarkable complications. This investigation highlights the role of pre-operative administration of a single dose of rectal diclofenac as a sole analgesic for early post-operative period.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Anaesthesiol. Clin. Pharmacol. [Field not mapped to EPrints] AD - Department of Anaesthesiology and Intensive Care, Babol University of Medical Sciences, Rohani Hospital, Ganj, Afroz Blv, Daneshgah Square, Babol, Mazandaran Province, Iran [Field not mapped to EPrints] AD - Department of Anaesthesiology and Intensive Care, Golestan University of Medical Sciences, Golestan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Pethidine, post-operative pain, shivering, suppository diclofenac, diclofenac, midazolam, pethidine, placebo, suppository base, adult, article, chill, controlled study, diastolic blood pressure, double blind procedure, female, heart rate, human, major clinical study, male, multicenter study, nociception, postoperative analgesia, postoperative nausea and vomiting, postoperative pain, postoperative period, prevalence, pruritus, randomized controlled trial, shivering, single drug dose, spinal anesthesia, systolic blood pressure, visual analog scale
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 07:16
Last Modified: 18 Apr 2015 07:16
URI: http://eprints.goums.ac.ir/id/eprint/1755

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