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Birth size in the most recent pregnancy and maternal mortality in premenopausal breast cancer by tumor characteristics

Hajiebrahimi, M. and Cnattingius, S. and Lambe, M. and Hsieh, C.-C. and Ahlgren, J. and Adolfsson, J. and Bahmanyar, S. (2014) Birth size in the most recent pregnancy and maternal mortality in premenopausal breast cancer by tumor characteristics. Breast Cancer Research and Treatment, 145 (2). pp. 471-480. ISSN 01676806 (ISSN)

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Abstract

The main aim of this study was to investigate possible associations between measures of offspring size at birth in the most recent pregnancy before premenopausal breast cancer diagnosis and the risks of maternal breast cancer mortality, taking tumor characteristics into account. We also aimed to investigate if these associations are modified by age at childbirth, time since childbirth, parity, and age at diagnosis. We followed 6,019 women from their date of premenopausal breast cancer (diagnosed from 1992 to 2008) until emigration, death or December 31st, 2009, whichever occurred first. We used Cox proportional hazard regression models, adjusted for parity, age at diagnosis, and education level, to estimate associations between women pregnancy, cancer characteristics and offspring birth characteristics, and mothers' mortality risk. In stratified analyses, mortality risks were estimated by tumor stage, ER or PR status. There was no association between offspring birth weight (HR = 1.00, 95 % CI 0.99-1.01, when used as a continuous variable), birth weight for gestational age or ponderal index, and premenopausal breast cancer mortality. Similarly, in analyses stratified by tumor stage, receptor status, and time difference between last pregnancy and date of diagnosis, we found no associations between birth size and breast cancer mortality. Our findings suggest that the hypothesis that "premenopausal breast cancer mortality is associated with offspring birth characteristics in the most recent pregnancy before the diagnosis" may not be valid. In addition, these associations are not modified by tumor characteristics. © 2014 Springer Science+Business Media New York.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Breast Cancer Res. Treat. [Field not mapped to EPrints] AD - Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden [Field not mapped to EPrints] AD - Department of Medicine, Center for Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] AD - Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA, United States [Field not mapped to EPrints] AD - Department of Oncology, �rebro University Hospital, �rebro, Sweden [Field not mapped to EPrints] AD - Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] AD - Department of Public Health, Public Health Faculty, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Birth size, Breast cancer, Estrogen receptor, Premenopausal, Progesterone receptor, estrogen receptor, progesterone receptor, adult, age, article, birth weight, breast cancer, cancer mortality, cancer risk, cancer staging, childbirth, cohort analysis, education, female, follow up, gestational age, human, infant, major clinical study, maternal mortality, parity, population research, pregnancy, premenopause, priority journal
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 10:12
Last Modified: 12 Mar 2016 06:16
URI: http://eprints.goums.ac.ir/id/eprint/1745

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