Golestan University of Medical Sciences Repository

Association of serum fetuin-A and biochemical parameters in hemodialysis patients.

Haddad, M. and Tajbakhsh, R. and Farajollahi, M. and Qorbani, M. and Besharat, S. and Joshaghani, H.R. (2014) Association of serum fetuin-A and biochemical parameters in hemodialysis patients. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 25 (4). pp. 769-773. ISSN 13192442 (ISSN)

[img]
Preview
PDF - Published Version
Download (94kB) | Preview

Abstract

Fetuin-A, a hepatic glycoprotein present in the circulation, is a potential inhibitor for systemic calcification. The main aim of this study was to evaluate the association between fetuin-A and other biochemical parameters as facilitator factors for developing atherosclerosis in hemodialysis (HD) patients. This case-control study was conducted on 44 HD patients undergoing treatment in 2012. Parathormone (i-PTH) and fetuin levels were performed by the enzyme-linked immunosorbent assay method, high-sensitivity C-reactive protein (hs-CRP) by chemiluminescence, low-density lipoprotein by direct enzymatic, calcium and albumin by colorimetric and phosphorous by ultraviolet (UV) methods. Chi-square was used for evaluating the association between variables and t-test was used for comparing the mean of the quantitative variables for the two groups. SPSS-16 software was used for data analysis and P-value less than 5% was considered as significant. Mean of serum fetuin level was 23.25 ± 4.90 ng/mL in HD patients and 32.92 ± 5.21 in the control group. Median of hs-CRP was 2.45 mg/dL in the patients and 1.00 mg/dL in the control group and i-PTH was 74.3 pg/mL in the patients and 7.30 pg/mL in the control group. The calcium-phosphorous product was 46.77 ± 14.22 mg/dL in the patient and 31.73 ± 6.48 mg/dL in the control group. A reverse significant association was found between fetuin-A and hs-CRP in this study. In this study, serum fetuin-A level in HD patients was lower than controls. Therefore, a low level of fetuin-A seems to be associated with atherosclerosis, inflammation and malnutrition.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Saudi J Kidney Dis Transpl [Field not mapped to EPrints] C2 - 24969186 [Field not mapped to EPrints] AD - Department of Medical Laboratory Sciences, Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran. [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: AHSG protein, human, ALB protein, human, biological marker, C reactive protein, calcium, fetuin A, parathyroid hormone, phosphorus, PTH protein, human, serum albumin, adult, aged, article, atherosclerosis, blood, case control study, chi square distribution, colorimetry, down regulation, enzyme linked immunosorbent assay, female, human, inflammation, male, malnutrition, middle aged, renal replacement therapy, risk assessment, risk factor, statistical model, treatment outcome, ultraviolet spectrophotometry, Adult, Aged, alpha-2-HS-Glycoprotein, Atherosclerosis, Biological Markers, C-Reactive Protein, Calcium, Case-Control Studies, Chi-Square Distribution, Colorimetry, Down-Regulation, Enzyme-Linked Immunosorbent Assay, Female, Humans, Inflammation, Logistic Models, Male, Malnutrition, Middle Aged, Parathyroid Hormone, Phosphorus, Renal Dialysis, Risk Assessment, Risk Factors, Serum Albumin, Spectrophotometry, Ultraviolet, Treatment Outcome
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 09:06
Last Modified: 04 May 2015 10:04
URI: http://eprints.goums.ac.ir/id/eprint/1742

Actions (login required)

View Item View Item