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The role of cognitive group therapy and happiness training on cerebral blood flow using 99mTc-ECD brain perfusion SPECT: A quasi-experimental study of depressed patients

Azizi, M. and Bahrieniain, S.A. and Baghdasarians, A. and Emamipur, S. and Azizmohammadi, Z. and Qutbi, S.M. and Javadi, H. and Assadi, M. and Asli, I.N. (2014) The role of cognitive group therapy and happiness training on cerebral blood flow using 99mTc-ECD brain perfusion SPECT: A quasi-experimental study of depressed patients. NuklearMedizin, 53 (5). pp. 205-210. ISSN 00295566 (ISSN)

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Abstract

Abstract Objective: The purpose of this study is to investigate the impact of cognitive group therapy and happiness training objectively in the local cerebral blood flow of patients with major depression (MD). Patients, material, methods: The present research is semi-experimental to pre- and post-test with a control group. Three groups were formed, and this number was incorporated in each group: 12 patients were chosen randomly; the first group of depressed patients benefited from the combination of pharmacotherapy and sessions of cognitive group therapy; the second group used a combination of pharmaco-therapy and sessions of happiness training; and a third group used only pharmacother-apy. We compared cognitive-behavioural therapy and happiness training efficacy with only pharmacotherapy in MD patients. We performed brain perfusion SPECT in each group, before and after each trial. Results: The study was conducted on 36 patients with MD (32 women and 4 men; mean age: 41.22 ± 9.08; range: 27–65 years). There were significant differences regarding the two trial effects into two experimental groups (p < 0/001) before and after trials, while such differences were not significant in the control group (p > 0.05). In addition, there was significant difference among the regional cerebral blood flow in the frontal and prefrontal regions into two experimental groups before and after trials (p < 0/001), while such differences were not significant in the control group (p > 0.05). Conclusion: This study demonstrated decreased cerebral perfusion in the frontal regions in MD patients, which increased following cognitive group therapy and happiness training. Because of its availability, low costs, easy performance, and the objective semi-quantitative information supplied, brain perfusion SPECT scanning might be useful to assess the diagnosis and therapy efficacy. Further exploration is needed to validate its clinical role. © Schattauer 2014.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] ST - Die wirkung der kognitiven gruppentherapie und des glückstrainings auf die zerebrale durchblu-tung mittels 99mTc-ECD hirndurchblutungs-SPECT eine quasi-experimentelle studie an depressiven patienten [Field not mapped to EPrints] J2 - NuklearMedizin [Field not mapped to EPrints] AD - Department of Psychology, Sarab Branch, Islamic Azad UniversitySarab, Iran [Field not mapped to EPrints] AD - Department of Psychology, Taleghani Hospital, Shahid Beheshti University of Medical SciencesTehran, Iran [Field not mapped to EPrints] AD - Islamic Azad University Central Tehran, Iran [Field not mapped to EPrints] AD - Department of Nuclear Medicine, Taleghani Hospital, Shahid Beheshti University of Medical SciencesTehran, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical SciencesGorgan, Iran [Field not mapped to EPrints] AD - The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical SciencesBushehr, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Brain perfusion SPECT, Cognitive group therapy, Happiness training, Major depression, sertraline, technetium 99m, adult, aged, Article, Beck Depression Inventory, brain blood flow, brain perfusion, clinical article, cognitive group therapy, controlled study, female, follow up, happiness training, human, major depression, male, oxford happiness inventory, post hoc analysis, psychologic test, psychotherapy, randomized controlled trial, single photon emission computer tomography
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 05:51
Last Modified: 17 Jan 2017 07:58
URI: http://eprints.goums.ac.ir/id/eprint/1733

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