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Herpes Simplex virus meningitis in children in South East of Caspian Sea, Iran

Azadfar, S. and Cheraghali, F. and Moradi, A. and Javid, N. and Tabarraei, A. (2014) Herpes Simplex virus meningitis in children in South East of Caspian Sea, Iran. Jundishapur Journal of Microbiology, 7 (1). ISSN 20083645 (ISSN)

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Background: Herpes simplex virus (HSV) is a member of Herpesviridae and a leading cause of human viral diseases. Meningitis occurs as a complication of HSV-1 or HSV-2 primary infection. Objectives: We aimed to evaluate HSV meningitis in children in Gorgan province, Iran. Patients and Methods: Forty-five cerebrospinal fluid samples were taken from children referred with meningitis symptoms. Samples with negative bacterial culture results were tested for viral, biochemical and cytological assays. DNA extraction and PCR were performed. Results: HSV-1 detected in 4 (8.8%) samples without any HSV-2 infections. Cases with positive results had fever and CSF pleocytosis. Vomiting, headache and higher count of WBC were observed in 3, 2 and 3 cases respectively. The cerebrospinal fluid (CSF) glucose and protein levels were normal and 3 cases showed positive C-reactive protein (CRP) results. Also erythrocyte sedimentation rate (ESR) was higher than normal in all positive cases. Conclusions: Distribution of HSV types in children with meningitis in our area predominantly was type 1 compared with type 2, which has been reported more in other area. © 2014, Ahvaz Jundishapur University of Medical Sciences; Published by Kowsar Corp.

Item Type: Article
Additional Information: Unmapped bibliographic data: C7 - e8599 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - Jundishapur J. Microbiol. [Field not mapped to EPrints] AD - Department of Microbiology, Infectious Diseases Research Centre, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Children, CSF, Herpes simplex virus, Meningitis, PCR, C reactive protein, DNA, article, bacterium culture, cerebrospinal fluid analysis, child, clinical article, controlled study, cytology, DNA extraction, erythrocyte sedimentation rate, female, headache, Herpes simplex virus, Herpes simplex virus 1, Herpes simplex virus 2, human, Iran, leukocyte, lumbar puncture, male, molecular diagnosis, pleocytosis, polymerase chain reaction, virus meningitis, vomiting
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 04:11
Last Modified: 24 Feb 2018 10:27
URI: http://eprints.goums.ac.ir/id/eprint/1731

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