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Impact of hepcidin antimicrobial peptide on iron overload in tuberculosis patients

Javaheri-Kermani, M. and Farazmandfar, T. and Ajami, A. and Yazdani, Y. (2014) Impact of hepcidin antimicrobial peptide on iron overload in tuberculosis patients. Scandinavian Journal of Infectious Diseases, 46 (10). pp. 693-696. ISSN 00365548 (ISSN)

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Abstract

Background: Iron acquisition is essential for the growth of Mycobacterium tuberculosis. Hepcidin is known as an antimicrobial peptide and a component of the innate immune response. Hepcidin inhibits M. tuberculosis growth in vitro. In this study, we decided to identify-582A> G variants of the HAMP promoter in patients with tuberculosis (TB) and investigate its effect on serum iron, ferritin, and hepcidin levels. Methods: The sample population consisted of 105 patients with TB and 104 healthy individuals. The-582A> G polymorphism was genotyped using a tetra-primers PCR set. Serum levels of hepcidin were determined using an ELISA kit. Statistical analysis was performed using SPSS software. Results: The G allele is meaningfully associated with TB disease (95% confidence interval = 2-4.8, p < 0.000). Significant differences were seen in the levels of serum iron and hepcidin but not ferritin between the-582A>G polymorphism genotypes. There was significant reverse correlation between hepcidin and iron (r =-0.849, p = 0.006). Conclusion: A high association was found between serum hepcidin levels and the HAMP-582A> G variants in patients with TB. These observations indicate a hypothetical role of this polymorphism in iron metabolism. Hepcidin could perhaps be an option for the treatment of TB. © 2014 Informa Healthcare.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Scand. J. Infect. Dis. [Field not mapped to EPrints] AD - Advanced Medical Science Technologies, Golestan University of Medical Sciences, Department of Molecular MedicineGorgan, Iran [Field not mapped to EPrints] AD - Molecular and Cell Biology Research Center, Mazandaran University of Medical SciencesSari, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Hepcidin, Iron, Polymorphism, Tuberculosis, ferritin, hepcidin, iron, allele, Article, controlled study, female, ferritin blood level, gene frequency, genetic association, genetic variability, genotype, human, iron blood level, iron metabolism, iron overload, major clinical study, male, medical record review, nucleotide sequence, promoter region, protein blood level, protein expression, single nucleotide polymorphism, tuberculosis
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 08:10
Last Modified: 05 May 2015 03:46
URI: http://eprints.goums.ac.ir/id/eprint/1730

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