Golestan University of Medical Sciences Repository

Helicobacter pylori infection and insulin resistance in diabetic and nondiabetic population

Vafaeimanesh, J. and Parham, M. and Seyyedmajidi, M. and Bagherzadeh, M. (2014) Helicobacter pylori infection and insulin resistance in diabetic and nondiabetic population. Scientific World Journal, 2014. ISSN 23566140 (ISSN)

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Abstract

Helicobacter pylori (HP) is a common worldwide infection with known gastrointestinal and nongastrointestinal complications. One of the gastrointestinal side effects posed for this organism is its role in diabetes and increased insulin resistance. The aim of this study was to evaluate the association between HP and insulin resistance in type 2 diabetic patients and nondiabetics. This cross-sectional study was carried out from May to December 2013 on 211 diabetic patients referred to diabetes clinic of Shahid Beheshti Hospital of Qom and 218 patients without diabetes. HP was evaluated using serology method and insulin resistance was calculated using HOMA-IR. The prevalence of H. pylori infection was 55.8% and 44.2% in diabetics and nondiabetics (P=0.001). The study population was divided into two HP positive and negative groups. Among nondiabetics, insulin resistance degree was 3.01±2.12 and 2.74±2.18 in HP+ and HP- patients, respectively P=0.704. Oppositely, insulin resistance was significantly higher in diabetic HP+ patients rather than seronegative ones (4.484±2.781 versus 3.160±2.327, P=0.013). In diabetic patients, in addition to higher prevalence of HP, it causes a higher degree of insulin resistance. © 2014 Jamshid Vafaeimanesh et al.

Item Type: Article
Additional Information: Unmapped bibliographic data: C7 - 391250 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - Sci. World J. [Field not mapped to EPrints] AD - Clinical Research Development Center, Department of Internal Medicine, Qom University of Medical SciencesQom, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical SciencesGorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: insulin, oral antidiabetic agent, adult, Article, controlled clinical trial, controlled study, cross-sectional study, diabetic patient, female, Helicobacter infection, human, insulin resistance, major clinical study, male, non insulin dependent diabetes mellitus, patient referral, prevalence, serology, Helicobacter pylori
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:38
Last Modified: 09 May 2015 06:50
URI: http://eprints.goums.ac.ir/id/eprint/1723

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