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Management of gastrointestinal complaints in differentiated thyroid cancer patients treated with 131I: Comparison of the efficacy of pantoprazole, metoclopra-mide, and ondansetron – a randomized clinical trial

Mirzababaee, M. and Shafiei, B. and Seifollahi, S. and Motazdian, M. and Fatholahi, L. and Delavari, S. and Naghshine, R. and Baharfar, N. and Tabeie, F. and Javadi, H. and Assadi, M. and Asli, I.N. (2014) Management of gastrointestinal complaints in differentiated thyroid cancer patients treated with 131I: Comparison of the efficacy of pantoprazole, metoclopra-mide, and ondansetron – a randomized clinical trial. NuklearMedizin, 53 (5). pp. 186-189. ISSN 00295566 (ISSN)

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Abstract

Objective: To compare safety and efficacy of pantoprazol, metoclopramide, ondansetron, as compared to placebo, in controlling gastrointestinal (GI) complaints of thyroid cancer patients treated with I-131these patients. Design: Four-armed, parallel group, single blind, randomized controlled clinical trial, setting: A university hospital, registration: database for clinical trials IRCT2013061713705N1. Patients: 85 patients with differentiated thyroid cancer who received131I. Main outcome measures: Post-radioiodine nausea and vomiting within three days of therapy (primary endpoint); occurrence of adverse reaction. Results: The patients' characteristics were similar within the study groups. Among the study variables, age, sex, administered dosage, history of previous GI complaints, and history of hyper -emesis gravidarum in female patients were not statistically different among the groups (p > 0.05). The results revealed that only ond-ansetron shows a therapeutic benefit over the placebo in controlling nausea (p < 0.05); however, it does not prevent vomiting (p > 0.05). The other two drugs, pantoprazole and meto-clopramide, did not control nausea (p > 0.05) or vomiting (p > 0.05). Conclusions: This study may demonstrate that the therapeutic dose of ondansetron could be an effective prophylactic agent in controlling GI complaints in differential thyroid carcinoma (DTC) patients following RAI therapy; however, these pre -liminary findings should be validated in larger studies. © Schattauer 2014.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] ST - Behandlung gastrointestinaler beschwerden unter 131I-therapie bei patienten mit differenzier-tem schilddrüsenkarzinom: Vergleich der wirksamkeit von pantoprazol, meto-clopramid und ondansetron � eine randomisierte klinische prüfung [Field not mapped to EPrints] J2 - NuklearMedizin [Field not mapped to EPrints] AD - Department of Nuclear Medicine, Taleghani Hospital, Shahid Beheshti University of Medical SciencesTehran, Iran [Field not mapped to EPrints] AD - Department of Nuclear Medicine, Arad HospitalTehran, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical SciencesGorgan, Iran [Field not mapped to EPrints] AD - The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical SciencesBushehr, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Differentiated thyroid cancer, Gastrointestinal complaint, Metoclopramide, Ondansetron, Pantoprazole, iodine 131, metoclopramide, ondansetron, pantoprazole, placebo, adult, Article, chemotherapy induced nausea and vomiting, comparative study, differentiated thyroid cancer, drug efficacy, drug safety, female, follicular carcinoma, gastrointestinal symptom, human, hurthle cell thyroid cancer, major clinical study, male, middle aged, nausea, nausea and vomiting, randomized controlled trial, single blind procedure, thyroid follicular carcinoma, thyroid papillary carcinoma
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 08:18
Last Modified: 07 Sep 2016 07:35
URI: http://eprints.goums.ac.ir/id/eprint/1716

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