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Association between 318C/T polymorphism of the CTLA-4 gene and systemic lupus erythematosus in Iranian patients

Shojaa, M. and Aghaie, M. and Amoli, M. and Javid, N. and Shakeri, F. and Khashayar, P. and Tabarraei, A. and Keshtkar, A.A. and Joshaghani, H.R. and Kouroshnia, A. and Qorbani, M. and Mahmoudi, F. and Mohebbi, R. and Ranjbarpour, N. (2014) Association between 318C/T polymorphism of the CTLA-4 gene and systemic lupus erythematosus in Iranian patients. International Journal of Rheumatic Diseases. ISSN 17561841 (ISSN) (In Press)

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Abstract

Background: Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an important negative regulator of T-cell response. It is a functional candidate gene connected with susceptibility to systemic lupus erythematosus (SLE). We analyzed the role of -318C/T polymorphism in the promoter region of the CTLA-4 gene in Iranian patients suffering from SLE. Methods: A total of 180 SLE patients and 304 healthy ethnically matched controls were enrolled in the study. DNA was extracted from blood samples according to the standard procedure. Polymerase chain reaction restriction fragments length polymorphism (PCR-RFLP) was used to analyze the genotype and allele frequencies of these polymorphisms. Results: The CC genotype was observed in 170 (94.5%) of the SLE patients, which was significantly different compared to the controls (251 [82.4%]; P = 0.0001, OR = 3.51 95%CI = 1.77-7.53). T allele was significantly more common in the controls (9.2%) compared to SLE patients 2.8% (P = 0.0001, OR = 0.26, 95%CI = 0.13-0.53). There was no significant correlation between different genotypes and age, gender or family history of SLE in the studied population. Conclusion: It can be concluded that -318C/T polymorphism of CTLA-4 gene might play a significant role in the development of SLE in the Iranian patients. © 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Int. J. Rheum. Dis. [Field not mapped to EPrints] AD - Golestan University of Medical Sciences Gorgan Iran [Field not mapped to EPrints] AD - Osteoporosis Research Center Endocrinology and Metabolism Clinical Sciences Institute Tehran University of Medical Sciences Tehran Iran [Field not mapped to EPrints] AD - Department of Rheumatology Faculty of Medicine Bone Joint and Connective Tissue Research Center (BJCRC) Golestan University of Medical Sciences Gorgan Iran [Field not mapped to EPrints] AD - Endocrinology and Metabolism Research Center (EMRC) Endocrinology and Metabolism Clinical Sciences Institute Tehran University of Medical Sciences Tehran Iran [Field not mapped to EPrints] AD - Department of Public Health Alborz University of Medical Sciences Karaj Iran [Field not mapped to EPrints] AD - Non-communicable Diseases Research Center Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences Tehran Iran [Field not mapped to EPrints] AD - Genetics Department Islamic Azad University Tehran Tehran Medical Branch Tehran Iran [Field not mapped to EPrints] AD - Medical School Shahed University of Medical Sciences Tehran Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: 318C/T, CTLA-4, Polymorphism, Promoter, Systemic lupus erythematosus
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:25
Last Modified: 09 May 2015 06:31
URI: http://eprints.goums.ac.ir/id/eprint/1707

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