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Association of helicobacter pylori infection with coronary artery disease: Is helicobacter pylori a risk factor?

Vafaeimanesh, J. and Hejazi, S.F. and Damanpak, V. and Vahedian, M. and Sattari, M. and Seyyedmajidi, M. (2014) Association of helicobacter pylori infection with coronary artery disease: Is helicobacter pylori a risk factor? The Scientific World Journal, 2014. ISSN 1537744X (ISSN)

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Abstract

Background. Helicobacter pylori (HP) infection is the most common infection in the world and coronary artery disease (CAD) is probably associated with it. The aim of this prospective study was to evaluate the association between HP infection and CAD in suspected patients referred for coronary angiography. The coronary angiography was performed using Judkins method and patients were assigned to participate in CAD positive (>50% luminal diameter stenosis) and negative groups. The serum HP IgG antibody was checked. Results. Positive and negative CAD groups consisted of 62 and 58 patients, respectively. HP was more prevalent among CAD+ patients, and with increasing the number of coronary arteries with stenosis, the HP seropositivity increased so that 76.3% of patients with multiple vessel diseases (MVD) and 70% of patients with single vessel diseases (SVD) were HP seropositive versus 50% in control group (P=0.006). Positive CAD was significantly associated with HDL level (P=0.01) and ESR level (P=0.006). Also, CAD+ patients had higher CRP levels than controls and it was statistically different between SVD group and controls (P<0.05). Conclusion. HP infection is more prevalent in CAD positive patients and, in case of proving causal relationship, it can be considered as a reversible risk factor for CAD. © 2014 Jamshid Vafaeimanesh et al.

Item Type: Article
Additional Information: Unmapped bibliographic data: C7 - 516354 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - Sci. World J. [Field not mapped to EPrints] C2 - 24574896 [Field not mapped to EPrints] AD - Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences (GOUMS), 10th Azar, 5 Azar Boulevard, Gorgan, Golestan Province, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: bacterium antibody, C reactive protein, high density lipoprotein, immunoglobulin G, adult, angiocardiography, blood, clinical trial, complication, coronary artery disease, Helicobacter Infections, Helicobacter pylori, human, male, metabolism, middle aged, prevalence, prospective study, radiography, risk factor, Adult, Antibodies, Bacterial, C-Reactive Protein, Coronary Angiography, Coronary Artery Disease, Helicobacter Infections, Helicobacter pylori, Humans, Immunoglobulin G, Lipoproteins, HDL, Male, Middle Aged, Prevalence, Prospective Studies, Risk Factors
Subjects: هیئت علمی
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:40
Last Modified: 09 May 2015 06:09
URI: http://eprints.goums.ac.ir/id/eprint/1699

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