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Determinants of gastroesophageal reflux disease, including hookah smoking and opium use- a cross-sectional analysis of 50,000 individuals

Islami, F. and Nasseri-Moghaddam, S. and Pourshams, A. and Poustchi, H. and Semnani, S. and Kamangar, F. and Etemadi, A. and Merat, S. and Khoshnia, M. and Dawsey, S.M. and Pharoah, P.D. and Brennan, P. and Abnet, C.C. and Boffetta, P. and Malekzadeh, R. (2014) Determinants of gastroesophageal reflux disease, including hookah smoking and opium use- a cross-sectional analysis of 50,000 individuals. PLoS ONE, 9 (2). ISSN 19326203 (ISSN)

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Abstract

Background: Gastroesophageal reflux disease (GERD) is a common cause of discomfort and morbidity worldwide. However, information on determinants of GERD from large-scale studies in low- to medium-income countries is limited. We investigated the factors associated with different measures of GERD symptoms, including frequency, patient-perceived severity, and onset time. Methods: We performed a cross-sectional analysis of the baseline data from a population-based cohort study of �50,000 individuals in in Golestan Province, Iran. GERD symptoms in this study included regurgitation and/or heartburn. Results: Approximately 20% of participants reported at least weekly symptoms. Daily symptoms were less commonly reported by men, those of Turkmen ethnicity, and nass chewers. On the other hand, age, body mass index, alcohol drinking, cigarette smoking, opium use, lower socioeconomic status, and lower physical activity were associated with daily symptoms. Most of these factors showed similar associations with severe symptoms. Women with higher BMI and waist to hip ratio were more likely to report frequent and severe GERD symptoms. Hookah smoking (OR 1.34, 95% CI 1.02-1.75) and opium use (OR 1.70, 95% CI 1.55-1.87) were associated with severe symptoms, whereas nass chewing had an inverse association (OR 0.87, 95% CI 0.76-0.99). After exclusion of cigarette smokers, hookah smoking was still positively associated and nass chewing was inversely associated with GERD symptoms (all frequencies combined). Conclusion: GERD is common in this population. The associations of hookah and opium use and inverse association of nass use with GERD symptoms are reported for the first time. Further studies are required to investigate the nature of these associations. Other determinants of GERD were mostly comparable to those reported elsewhere. © 2014 Islami et al.

Item Type: Article
Additional Information: Unmapped bibliographic data: C7 - e89256 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - PLoS ONE [Field not mapped to EPrints] C2 - 24586635 [Field not mapped to EPrints] AD - Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Tisch Cancer Institute and Institute for Transitional Epidemiology, Mount Sinai School of Medicine, New York, NY, United States [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore, MD, United States [Field not mapped to EPrints] AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States [Field not mapped to EPrints] AD - Departments of Oncology and Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom [Field not mapped to EPrints] AD - International Agency for Research on Cancer, Lyon, France [Field not mapped to EPrints] AD - International Prevention Research Institute, Lyon, France [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: opiate, opiate, adult, age distribution, article, body mass, controlled study, cross-sectional study, disease severity, drinking behavior, educational status, ethnicity, female, gastroesophageal reflux, hookah smoking, human, major clinical study, male, onset age, physical activity, prevalence, sex difference, smoking, social status, waist circumference, waist hip ratio, aged, complication, epidemiology, gastroesophageal reflux, Iran, middle aged, opiate addiction, risk factor, severity of illness index, smoking, socioeconomics, symptom assessment, Adult, Aged, Alcohol Drinking, Cross-Sectional Studies, Female, Gastroesophageal Reflux, Humans, Iran, Male, Middle Aged, Opioid-Related Disorders, Opium, Prevalence, Risk Factors, Severity of Illness Index, Sex Factors, Smoking, Socioeconomic Factors, Symptom Assessment
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 04:11
Last Modified: 04 May 2015 15:32
URI: http://eprints.goums.ac.ir/id/eprint/1698

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