Zahedpasha, Y. and Ahmadpour, M. and Niaki, H.A. and Alaee, E. (2014) Relation between neonatal icter and gilbert syndrome in gloucose-6-phosphate dehydrogenase deficient subjects. Journal of Clinical and Diagnostic Research, 8 (3). pp. 63-65. ISSN 2249782X (ISSN)
Full text not available from this repository.Abstract
Background and Aim: The pathogenesis of neonatal hyperbilirubinemia hasn't been completely defined in Gloucose-6-Phosphate Dehydrogenase (G6PD) deficient newborns. The aim of this study was to detect the relationship between Gilbert's syndrome and hyperbilirubinemia in Gloucose-6-Phosphate Dehydrogenase (G6PD) deficient neonates. Materials and Methods: This case-control study was conducted in Amirkola pediatrics teaching hospital, Babol, Iran. A total number of one hundred four infants were included in the study (51 infants with neonatal jaundice and Gloucose-6-Phosphate Dehydrogenase (G6PD) deficiency admitted to phototherapy or transfusion were selected as the case group and 53 infants with Gloucose-6-Phosphate Dehydrogenase (G6PD) deficiency admitted for other reasons than jaundice were selected as the control group). Exclusion criteria were ABO or Rh incompatibility or other reasons that made Coombs test positive, sepsis, hepatosplenomegaly, metabolic diseases, medical treatment and phototherapy. The promoter and coding regions of Uridine diphosphate Glucuronosyl Transferase 1A1 (UGT1A1) of genomic DNA were amplified by polymerase chain reaction (PCR) isolated from leukocytes. We used chi-square test and t-test to compare cases and controls. Results: Distribution of Gilbert genome was not significantly different between the two groups; among cases, 33.3% were homozygote, 35.3% heterozygote, and 31.4% normal. Among controls, 22.6% were homozygote, 34% heterozygote, and 43.4% normal (p-value=xxx). Hyperbilirubinemia family history didn't differ significantly between these two groups. Conclusions: We showed that in Gloucose-6-Phosphate Dehydrogenase (G6PD) deficient neonates, there was no significant association between Gilbert's syndrome (promoter polymorphism) and hyperbilirubinemia.
| Item Type: | Article |
|---|---|
| Additional Information: | Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Clin. Diagn. Res. [Field not mapped to EPrints] AD - Paediatric Research Center, Amirkola Children Hospital, Department of Paediatric, School of Medicine, Babol University of Medical Sciences, Babol, Iran [Field not mapped to EPrints] AD - Cellular and Molecular Biology Research Center (CMBRC) of Babol University of Medical Sciences, Iran [Field not mapped to EPrints] AD - Neonatal and Children's Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints] |
| Uncontrolled Keywords: | G6PD deficiency, Glucuronosyl-transferase 1A1, Neonatal jaundice, Uridine diphosphate, genomic DNA, uridine diphosphate, article, case control study, controlled study, DNA extraction, female, Gilbert disease, glucose 6 phosphate dehydrogenase deficiency, human, major clinical study, male, neonatal hyperbilirubinemia, newborn, newborn jaundice, pathogenesis, polymerase chain reaction, promoter region, sequence analysis |
| Subjects: | مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus |
| Divisions: | معاونت تحقیقات و فناوری |
| Depositing User: | GOUMS |
| Date Deposited: | 18 Apr 2015 08:44 |
| Last Modified: | 23 May 2015 07:08 |
| URI: | http://eprints.goums.ac.ir/id/eprint/1695 |
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