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Topographical disorientation after ischemic mini infarct in the dorsal hippocampus: Whispers in silence

Faraji, J. and Soltanpour, N. and Moeeini, R. and Roudaki, S. and Soltanpour, N. and Abdollahi, A.A. and Metz, G.A.S. (2014) Topographical disorientation after ischemic mini infarct in the dorsal hippocampus: Whispers in silence. Frontiers in Behavioral Neuroscience, 8 (AUG). ISSN 16625153 (ISSN)

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Abstract

Silent focal ischemic mini infarcts in the brain are thought to cause no clinically overt symptoms. Some populations of hippocampal cells are particularly sensitive to ischemic events, however, rendering hippocampal functions especially vulnerable to ischemiainduced deficits. The present study investigated whether an otherwise silent ischemic mini infarct in the hippocampus (HPC) can produce impairments in spatial performance in rats. Spatial performance was assessed in the ziggurat task (ZT) using a 10-trial spatial learning protocol for 4 days prior to undergoing hippocampal ischemic lesion or sham surgery. Hippocampal silent ischemia was induced by infusion of endothelin-1 (ET-1), a potent vasoconstrictor, into either the dorsal or the ventral hippocampus (dHPC and vHPC). When tested postoperatively in the ZT using a standard testing protocol for 8 days, rats with hippocampal lesions exhibited no spatial deficit. Although spatial learning and memory in the ZT were not affected by the ET-1-induced silent ischemia, rats with dHPC stroke showed more returns when navigating the ZT as opposed to the vHPC rats. Comparison of region-specific HPC lesions in the present study indicated that dorsal hippocampal function is critically required for topographic orientation in a complex environment. Topographic disorientation as reflected by enhanced return behaviors may represent one of the earliest predictors of cognitive decline after silent ischemic insult that may be potentially traced with sensitive clinical examination in humans. © 2014 Faraji, Soltanpour, Moeeini, Roudaki, Soltanpour, Abdollahiand Metz.

Item Type: Article
Additional Information: Unmapped bibliographic data: C7 - 261 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - Front. Behav. Neurosci. [Field not mapped to EPrints] AD - Department of Neuroscience, Canadian Centre for Behavioural Neuroscience (CCBN), University of Lethbridge, Lethbridge, AB, Canada [Field not mapped to EPrints] AD - Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Anatomy, Biology and Molecular Research Center, Babol University of Medical Sciences, Babol, Iran [Field not mapped to EPrints] AD - Department of Behavioural Studies, Avicenna Institute of Neuroscience, Yazd, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Early cognitive decline, Endotelin-1, Hippocampus, Return behavior, Silent stroke, Spatial navigation, Topographical disorientation, Ziggurat task, animal experiment, animal model, animal tissue, article, brain infarction, controlled study, disorientation, hippocampus, histopathology, latent period, male, nonhuman, rat, spatial learning, spatial memory, spatial orientation, task performance
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Apr 2015 09:39
Last Modified: 19 May 2015 04:21
URI: http://eprints.goums.ac.ir/id/eprint/1687

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