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Encapsulation of curcumin in diblock copolymer micelles for cancer therapy

Alizadeh, A.M. and Sadeghizadeh, M. and Najafi, F. and Ardestani, S.K. and Erfani-Moghadam, V. and Khaniki, M. and Rezaei, A. and Zamani, M. and Khodayari, S. and Khodayari, H. and Mohagheghi, M.A. (2015) Encapsulation of curcumin in diblock copolymer micelles for cancer therapy. BioMed Research International, 2015. ISSN 23146133 (ISSN)

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Abstract

Application of nanoparticles has recently promising results for water insoluble agents like curcumin. In this study, we synthesized polymeric nanoparticle-curcumin (PNPC) and then showed its efficiency, drug loading, stability, and safety. Therapeutic effects of PNPC were also assessed on two cell lines and in an animal model of breast cancer. PNPC remarkably suppressed mammary and hepatocellular carcinoma cells proliferation (P < 0.05). Under the dosing procedure, PNPC was safe at 31.25 mg/kg and lower doses. Higher doses demonstrated minimal hepatocellular and renal toxicity in paraclinical and histopathological examinations. Tumor take rate in PNPC-treated group was 37.5% compared with 87.5% in control (P < 0.05). Average tumor size and weight were significantly lower in PNPC group than control (P < 0.05). PNPC increased proapoptotic Bax protein expression (P < 0.05). Antiapoptotic Bcl-2 protein expression, however, was lower in PNPC-treated animals than the control ones (P < 0.05). In addition, proliferative and angiogenic parameters were statistically decreased in PNPC-treated animals (P < 0.05). These results highlight the suppressing role for PNPC in in vitro and in vivo tumor growth models. Our findings provide credible evidence for superior biocompatibility of the polymeric nanocarrier in pharmacological arena together with an excellent tumor-suppressing response. © 2015 Ali Mohammad Alizadeh et al.

Item Type: Article
Additional Information: Unmapped bibliographic data: C7 - 824746 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - BioMed Res. Int. [Field not mapped to EPrints] AD - Cancer Research Center, Tehran University of Medical SciencesTehran, Iran [Field not mapped to EPrints] AD - Department of Genetics, School of Biological Sciences, Tarbiat Modares UniversityTehran, Iran [Field not mapped to EPrints] AD - Department of Resin and Additives, Institute for Color Science and TechnologyTehran, Iran [Field not mapped to EPrints] AD - Immunology Lab, Institute of Biochemistry and Biophysics, University of TehranTehran, Iran [Field not mapped to EPrints] AD - Department of Biotechnology, Faculty of Advanced Medical Technology, Golestan University of Medical SciencesGorgan, Iran [Field not mapped to EPrints] AD - Department of Pathology, School of Medicine, Tehran University of Medical SciencesTehran, Iran [Field not mapped to EPrints] AD - School of Biological Science, Damghan UniversityDamghan, Iran [Field not mapped to EPrints] AD - Cancer Model Research Center, Tehran University of Medical SciencesTehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: curcumin, cyclophosphamide, doxorubicin, nanocarrier, protein Bax, protein bcl 2, animal experiment, animal tissue, antineoplastic activity, Article, ascites, atomic force microscopy, biocompatibility, breast cancer, cancer cell culture, cancer therapy, controlled study, critical micelle concentration, diarrhea, female, histopathology, human, immunohistochemistry, in vitro study, in vivo study, liver cell carcinoma, micelle, mouse, nanoencapsulation, nephrotoxicity, nonhuman, particle size, protein expression, tumor volume, weight reduction, zeta potential, Animalia
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Apr 2015 09:45
Last Modified: 25 Dec 2016 05:47
URI: http://eprints.goums.ac.ir/id/eprint/1656

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