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Assessment of bone mineral density in patients undergoing hemodialysis; An Iranian population-based study

Amirkhanlou, S. and Roshandel, G. and Aghaei, M. and Mohebi, H. and Tabatabei, S.-S. and Momen, S. and Zia, P. and Aarabi, M. and Amouzadeh, F. and Hosseininejad, S.-M. (2021) Assessment of bone mineral density in patients undergoing hemodialysis; An Iranian population-based study. Archives of Iranian Medicine, 24 (8). pp. 599-606.

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Abstract

Background: End-stage renal disease (ESRD) is a condition in which bone turnover and metabolism is impaired; thus, osteoporosis and low bone density are subsequently inevitable. We aimed to determine bone mineral density (BMD) and biochemical markers, and associated factors in hemodialysis (HD) patients. Methods: Patients aged 30-70 years undergoing HD between 2015 to 2019 were enrolled in this cross-sectional study. BMD measured by dual energy x-ray absorptiometry (DEXA) and biochemical laboratory tests were assessed in 200 patients undergoing HD. Statistical analysis was based on t test, Pearson, regression and Mann-Whitney tests using SPSS 16. Results: Two hundred patients were investigated. Sixty percent of the patients were female. Mean ± SD of participants' age was 58.6 (±11.63) years and mean ± SD for duration of HD was 45.69 (± 43.76) months. Osteoporosis was found in 48 (n = 96) and low bone density in 36 (n = 76) of our patients. General osteoporosis was more frequent in those undergoing HD for more than 3 years, although not significantly (P = 0.093, odds ratio OR = 0.37). However, regional osteoporosis in hip and femoral neck, but not spine vertebrae, were significantly higher after three years of HD (P = 0.036, OR = 0.27; P = 0.042, OR = 0.27; and P = 0.344, OR = 0.56, respectively). Increased body mass index (BMI) correlated negatively with osteoporosis (P = 0.050). Conclusion: With increasing age and duration of HD, BMD decreases. Higher BMI was associated with higher bone mass density. Bone density assessment seems to be necessary in patients undergoing HD. © 2021 Academy of Medical Sciences of I.R. Iran. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: biochemical marker; biological marker; colecalciferol; parathyroid hormone, adult; aged; Article; body mass; bone density; bone metabolism; bone turnover; calcium blood level; controlled study; cross-sectional study; dual energy X ray absorptiometry; female; hemodialysis; hemodialysis patient; human; hypertension; Iranian people; major clinical study; male; osteoporosis; risk factor
Subjects: سیستم ادراری WJ
سیستم عضلانی ، اسکلتی WE
پرستاری wy
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 03 Oct 2021 06:01
Last Modified: 03 Oct 2021 06:01
URI: http://eprints.goums.ac.ir/id/eprint/11218

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