Golestan University of Medical Sciences Repository

The role of vitamin D in the age of COVID-19: A systematic review and meta-analysis

Ghasemian, R. and Shamshirian, A. and Heydari, K. and Malekan, M. and Alizadeh-Navaei, R. and Ebrahimzadeh, M.A. and Ebrahimi Warkiani, M. and Jafarpour, H. and Razavi Bazaz, S. and Rezaei Shahmirzadi, A. and Khodabandeh, M. and Seyfari, B. and Motamedzadeh, A. and Dadgostar, E. and Aalinezhad, M. and Sedaghat, M. and Razzaghi, N. and Zarandi, B. and Asadi, A. and Yaghoubi Naei, V. and Beheshti, R. and Hessami, A. and Azizi, S. and Mohseni, A.R. and Shamshirian, D. (2021) The role of vitamin D in the age of COVID-19: A systematic review and meta-analysis. International Journal of Clinical Practice.

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Abstract

Background: Evidence recommends that vitamin D might be a crucial supportive agent for the immune system, mainly in cytokine response regulation against COVID-19. Hence, we carried out a systematic review and meta-analysis in order to maximise the use of everything that exists about the role of vitamin D in the COVID-19. Methods: A systematic search was performed in PubMed, Scopus, Embase and Web of Science up to December 18, 2020. Studies focused on the role of vitamin D in confirmed COVID-19 patients were entered into the systematic review. Results: Twenty-three studies containing 11 901 participants entered into the meta-analysis. The meta-analysis indicated that 41 of COVID-19 patients were suffering from vitamin D deficiency (95 CI, 29-55), and in 42 of patients, levels of vitamin D were insufficient (95 CI, 24-63). The serum 25-hydroxyvitamin D concentration was 20.3 ng/mL among all COVID-19 patients (95 CI, 12.1-19.8). The odds of getting infected with SARS-CoV-2 are 3.3 times higher among individuals with vitamin D deficiency (95 CI, 2.5-4.3). The chance of developing severe COVID-19 is about five times higher in patients with vitamin D deficiency (OR: 5.1, 95 CI, 2.6-10.3). There is no significant association between vitamin D status and higher mortality rates (OR: 1.6, 95 CI, 0.5-4.4). Conclusion: This study found that most of the COVID-19 patients were suffering from vitamin D deficiency/insufficiency. Also, there is about three times higher chance of getting infected with SARS-CoV-2 among vitamin-D-deficient individuals and about five times higher probability of developing the severe disease in vitamin-D-deficient patients. Vitamin D deficiency showed no significant association with mortality rates in this population. © 2021 John Wiley & Sons Ltd

Item Type: Article
Additional Information: cited By 0
Subjects: سیستم تنفسی WF
بیماریهای واگیرWC
QU بیوشیمی
میکروب شناسی وایمنی شناسی QW
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Aug 2021 08:06
Last Modified: 14 Aug 2021 08:06
URI: http://eprints.goums.ac.ir/id/eprint/11180

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