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Evaluation of type ii toxin-antitoxin systems, antibiotic resistance pro-files, and biofilm quorum sensing genes in acinetobacter baumannii isolates in Iraq

Al Marjania, M.F. and Kouhsari, E. and Ali, F.S. and Authman, S.H. (2021) Evaluation of type ii toxin-antitoxin systems, antibiotic resistance pro-files, and biofilm quorum sensing genes in acinetobacter baumannii isolates in Iraq. Infectious Disorders - Drug Targets, 21 (2). pp. 187-193.

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Abstract

Background: Bacterial Toxin-Antitoxin (TAs) systems are extensive two-component el-ements in the bacterial genome, which are involved in many key biological functions, including growth arrest, survival, biofilm formation, plasmid maintenance, defense against phages, persis-tence, and virulence. Aim: This study aimed to assess the molecular determinants involved in TAs, biofilm quorum sens-ing, and antibiotic resistance profiles in Acinetobacter baumannii isolated from Baghdad�s hospitals in Iraq. Methods: A total of 127 A. baumannii isolates were collected from 2160 different clinical samples. The antimicrobial susceptibility test was performed using the disk diffusion test. All isolates were characterized for molecular determinants involved in TAs and biofilm formation using the well--known PCR-based sequencing assay. Results: A high multi-drug resistant (MDR) (96.06; 122/127) and imipenem resistance (84.25; 107/127) rates were observed from A.baumannii isolates. Results showed the presence of rhlIR gene in three isolates (2.36), and lasIR gene appeared in two isolates (1.57) isolates, whilst, mazEF, ccdAB, and relBE genes have not been detected among any of the isolates. Conclusion: A high MDR and imipenem resistance rates within a low prevalence of rhlIR, and lasIR genes could be found in clinical A. baumannii isolates from some of the Iraqi hospitals. © 2021 Bentham Science Publishers.

Item Type: Article
Additional Information: cited By 0
Subjects: QU بیوشیمی
فارماکولوژی QV > سم شناسی QV
> دانشکده داروسازی > فارماکولوژی QV > سم شناسی QV

میکروب شناسی وایمنی شناسی QW
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 03 Mar 2021 08:55
Last Modified: 03 Mar 2021 08:55
URI: http://eprints.goums.ac.ir/id/eprint/10987

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