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Plasma changes of branched-chain amino acid in patients with esophageal cancer

Taherizadeh, M. and Khoshnia, M. and Shams, S. and Hesari, Z. and Joshaghani, H. (2021) Plasma changes of branched-chain amino acid in patients with esophageal cancer. Middle East Journal of Digestive Diseases, 13 (1). pp. 49-53.

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Abstract

BACKGROUND Studies have indicated that branched amino acids play a crucial role in gene expression, protein metabolism, apoptosis, and restoration of hepatocytes and insulin resistance. This study aimed to compare the plasma levels of branched-chain amino acids in patients with esophageal cancer and normal individuals. METHODS Plasma levels of leucine and isoleucine of 37 patients with esophageal cancer and 37 healthy adults were investigated by high-pressure liquid chromatography. Data analysis was performed using SPSS (version 16) software, and t test was used to compare the plasma levels of branched-chain amino acids in the two groups. RESULTS In the patients group, the mean age ± SD was 63 ± 13.64 years, and 21 (56.8) individuals were male. In the control group, the mean age ± SD was 64.24 ± 13.08 years, and 21 (54.1) individuals were male. Plasma levels of leucine (37.68 ± 105) and isoleucine (22.43 ± 59.1) in patients with esophageal cancer were significantly reduced (p value of isoleucine:0.007, and leucine: 0.0001). CONCLUSION In the present study, the plasma levels of branched-chain amino acids in patients with esophageal cancer had changed. Evidence suggests that branched-chain amino acids are essential nutrients for cancer growth and are used by tumors in various biosynthetic pathways as energy sources. Thus, studies in this field can be useful in providing appropriate therapeutic approaches. © 2021 The Author(s).

Item Type: Article
Additional Information: cited By 0
Subjects: سیستم گوارشی WI
سیستم های خونی و لنفاوی WH
QU بیوشیمی
آسیب شناسی بالینی QY
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 23 Feb 2021 07:02
Last Modified: 23 Feb 2021 07:02
URI: http://eprints.goums.ac.ir/id/eprint/10961

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