Golestan University of Medical Sciences Repository

Preconditioning and anti-apoptotic effects of Metformin and Cyclosporine-A in an isolated bile duct-ligated rat heart

Moheimani, H.R. and Amiriani, T. and Alizadeh, A.M. and Jand, Y. and Shakiba, D. and Ensan, P.S. and Jafarzadeh, F. and Rajaei, M. and Enayati, A. and Pourabouk, M. and Aliazadeh, S. and Pourkhani, A.H. and Mazaheri, Z. and Zeyghami, M.A. and Dehpour, A. and Khori, V. (2021) Preconditioning and anti-apoptotic effects of Metformin and Cyclosporine-A in an isolated bile duct-ligated rat heart. European Journal of Pharmacology, 893.

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Abstract

Despite all previous studies relating to the mechanism of cirrhotic cardiomyopathy (CCM), the role of cirrhosis on Ischemic Preconditioning (IPC) has not yet been explored. The present study strives to assess the cardioprotective role of IPC in bile duct ligated (BDL) rats as well as the cardioprotective role of Cyclosporin-A (CsA) and Metformin (Met) in CCM. Cirrhosis was induced by bile duct ligation (BDL). Rats� hearts were isolated and attached to a Langendorff Apparatus. The pharmacological preconditioning with Met and CsA was done before the main ischemia. Myocardial infarct size, hemodynamic and electrophysiological parameters, biochemical markers, and apoptotic indices were determined at the end of the experiment. Infarct size, apoptotic indices, arrhythmia score, and incidence of VF decreased significantly in the IPC group in comparison with the I/R group. These significant decreases were abolished in the IPC (BDL) group. Met significantly decreased the infarct size and apoptotic indices compared with I/R (BDL) and normal groups, while CsA led to similar decreases except in the level of caspase-3 and -8. Met and CsA decreased and increased the arrhythmia score and incidence of VF in the BDL groups, respectively. Functional recovery indices decreased in the I/R (BDL) and IPC (BDL) groups. Met improved these parameters. Therefore, the current study depicted that the cardioprotective effect of Met and CsA on BDL rats is mediated through the balance between pAMPK and apoptosis in the mitochondria. © 2020 Elsevier B.V.

Item Type: Article
Additional Information: cited By 0
Subjects: سیستم قلب وعروق WG
QS آناتومی انسان
QTفیزیولوژی
فارماکولوژی QV
> دانشکده داروسازی > فارماکولوژی QV

میکروب شناسی وایمنی شناسی QW
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 23 Feb 2021 09:03
Last Modified: 23 Feb 2021 09:03
URI: http://eprints.goums.ac.ir/id/eprint/10946

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