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Tehran environmental and neurodevelopmental disorders (TEND) cohort study: Phase I, feasibility assessment

Shamsipour, M. and Pirjani, R. and Jeddi, M.Z. and Effatpanah, M. and Rastkari, N. and Kashani, H. and Shirazi, M. and Hassanvand, M.S. and NinoKünzli, and Shariat, M. and Javadi, F.S. and Shariatpanahi, G. and Hassanpour, G. and Peykarporsan, Z. and Jamal, A. and Ardestani, M.E. and Hoseini, F.S. and Dalili, H. and Nayeri, F.S. and Mesdaghinia, A. and Naddafi, K. and Shahtaheri, S.J. and Nasseri, S. and Yunesian, F. and Rezaeizadeh, G. and Amini, H. and Yokoyama, K. and Vigeh, M. and Yunesian, M. and Golnaz Rezaeizadeh, and Heresh Amini, and Kazuhito Yokoyama, and Mohsen Vigeh, and Masud Yunesian, and Corresponding author for this work, (2020) Tehran environmental and neurodevelopmental disorders (TEND) cohort study: Phase I, feasibility assessment. Journal of Environmental Health Science and Engineering, 18 (2). pp. 733-742.

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Purpose: To advance knowledge about childhood neurodevelopmental disorders and study their environmental determinants, we conducted a study in Tehran, Iran to assess the feasibility of prospective birth cohort study. Methods: We evaluated participation of pregnant women, feasibility of sampling biological material, and health care services availability in Tehran in four steps: (1) first trimester of pregnancy; (2) third trimester of pregnancy; (3) at delivery; and (4) two to three months after delivery. We collected related data through questionnaires, also various biological samples were obtained from mothers (blood, urine, milk and nails�hands and feet) and newborns (umbilical cord blood, meconium, and urine samples) from February 2016 to October 2017. Results: overall 838 eligible pregnant women were approached. The participation rate was 206(25) in our study and about 185(90) of subjects were recruited in hospitals. Out of 206 participants in the first trimester, blood, urine, hand nail, and foot nail samples were collected from 206(100),193(93), 205(99), and 205(99), respectively. These values dropped to 65(54), 83(69), 84(70), and 84(70) for the remaining participants 120(58) in the third trimester, respectively. Also, we gathered milk samples from 125(60) of mothers at two to three months after delivery. Conclusion: Our findings suggest that hospitals were better places for recruitment of subjects in a birth cohort in Tehran. We further concluded that birth cohort study recruitment can be improved by choosing appropriate gestational ages. Obtaining the newborn�s urine, meconium, and umbilical cord blood were challenging procedures and require good collaboration between hospital staff and researchers. © 2020, Springer Nature Switzerland AG.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: biomonitoring; chemical substance; child health; cohort analysis; feasibility study; health services; nervous system disorder; pregnancy, Iran; Tehran Iran
Subjects: سیستم عصبی WL
QS آناتومی انسان
حرفه پزشکی W
بهداشت عمومی WA > بهداشت محیط WA
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 03 Jan 2021 06:36
Last Modified: 03 Jan 2021 06:36
URI: http://eprints.goums.ac.ir/id/eprint/10882

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