Golestan University of Medical Sciences Repository

Evaluation of the Xpert MTB/RIF test accuracy for diagnosis of tuberculosis in areas with a moderate tuberculosis burden

Mansoori, N. and Pahlavanzadeh, B. and Arabmofrad, F. (2020) Evaluation of the Xpert MTB/RIF test accuracy for diagnosis of tuberculosis in areas with a moderate tuberculosis burden. APMIS.

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Abstract

The Xpert MTB/RIF assay (Xpert) is a molecular assay used for direct detection of Mycobacterium tuberculosis (MTB) in clinical specimens. In this study, we aimed to assess the accuracy of the Xpert assay for the diagnosis of tuberculosis (TB) in TB suspected patients from the northern region of Iran. The obtained results were compared with the culture method. The sputum specimens were examined using the Xpert assay, smear microscopy, and solid culture media as a reference diagnostic tool. Among 293 presumptive TB cases, 92 (31.4) were positive according to the culture method. The Xpert method detected 88 (95.7) cases that were positive according to the culture method, compared with 78 (84.8) positive cases according to smear microscopy. The overall sensitivity and specificity of the Xpert method for TB diagnosis were 95.7 and 99, respectively. Also, the sensitivity and specificity for smear microscopy were 84.8 and 97.5, respectively. The Xpert assay showed high overall sensitivity and specificity; thus, it can be effectively used for the early and accurate diagnosis of MTB in TB endemic areas. In addition, the agreement between semi-quantitative results of Xpert and smear microscopy assays could be helpful in evaluating transmission potential in TB patients. © 2020 Scandinavian Societies for Medical Microbiology and Pathology

Item Type: Article
Additional Information: cited By 0
Subjects: سیستم تنفسی WF
بیماریهای واگیرWC
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 31 Oct 2020 09:04
Last Modified: 31 Oct 2020 09:04
URI: http://eprints.goums.ac.ir/id/eprint/10838

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