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Comparative study of urinary minerals and their effect on stone formation in two groups of cystic fibrosis (Cf) and healthy children

Niknahad, A. and Shahkar, L. and Kompani, F. and Montazeri, M. and Azar, A.A. (2020) Comparative study of urinary minerals and their effect on stone formation in two groups of cystic fibrosis (Cf) and healthy children. Nephro-Urology Monthly, 12 (3). pp. 1-6.

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Background: Cystic Fibrosis (CF) is a systemic autosomal disorder and the most important chronic lung disease in children. Oxalate is the end product of vitamin C metabolism, which increases the risk of kidney stones, urinary bladder stones, and calcium deposits in CF patients. Objectives: Considering the increased mineral excretion and the rate of stone formation in the urinary tract, examining the excretion of minerals will greatly help resolve clinical problems. Methods: This descriptive-analytical study was performed on CF and healthy children in Gorgan in 2018-19. In this study, 40 CF children and 40 healthy children were randomly selected. After obtaining informed consent from the parents of the children, a random urine sample was collected to evaluate urine minerals. Children with abnormal urinary mineral excretion underwent ul-trasonography. The data were analyzed by SPSS 18 using descriptive indices (mean ± SD, frequency, and percentage) and statistical tests (independent t-test, chi-square test, and nonparametric tests). Results: Out of 80 CF and healthy children, 34 were girls, and the rest was boys. The mean age of the patients was 4.34 ± 3.38. The age difference was not significant between the groups (P > 0.05). The mean urinary levels of phosphorus, uric acid, magnesium, and citrate were 0.87 ± 1.01, 1.16 ± 0.68, 0.23 ± 0.18, 2.37 ± 3.13 mg/mg of creatinine. In the pediatric patient group, respectively (P < 0.001). The mean urinary calcium level in CF patients was 0.28 ± 0.39, which was lower than that in the healthy group. The mean urinary oxalate level was 0.13 ± 0.20 in CF patients, which was higher than that in the healthy group (P > 0.05). Hyperoxaluria, hyperuricosuria, hypomagnesiuria, and hypocitraturia occurred in 35, 30, 62, and 7.5 of the CF patients, respectively. Among the urinary minerals studied, hyperoxaluria was found to be a major determinant of stone formation risk in CF. No correlation was observed between the formation of stones and the rate of excretion of minerals (P > 0.05). Conclusions: In summary, CF patients are at an increased risk of developing citrate and calcium stones compared to the healthy group, which is associated with hyperuricosuria, hypocitraturia, and hyperoxaluria. © 2020 Global Research Online. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: citric acid; magnesium; mineral; oxalic acid; phosphorus; uric acid, Article; calcium stone; case control study; child; clinical article; comparative study; cystic fibrosis; echography; female; human; hypercalciuria; hyperoxaluria; hyperuricosuria; hypomagnesemia; major clinical study; male; preschool child; stone formation; urinalysis
Subjects: سیستم ادراری WJ
سیستم تنفسی WF
بیماریهای کودکانWS
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 13 Sep 2020 08:08
Last Modified: 13 Sep 2020 08:08
URI: http://eprints.goums.ac.ir/id/eprint/10781

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