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Overview of the current promising approaches for the development of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine

Mirzaei, R. and Mohammadzadeh, R. and Mahdavi, F. and Badrzadeh, F. and Kazemi, S. and Ebrahimi, M. and Soltani, F. and Kazemi, S. and Jeda, A.S. and Darvishmotevalli, M. and Yousefimashouf, R. and Keyvani, H. and Karampoor, S. (2020) Overview of the current promising approaches for the development of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. International Immunopharmacology, 88.

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Abstract

Coronavirus disease 2019 (COVID-19) is a pandemic infectious disease caused by the novel coronavirus called SARS-CoV-2. There is a gap in our understanding regarding the immunopathogenesis of COVID-19. However, many clinical trials are underway across the world for screening effective drugs against COVID-19. Nevertheless, currently, no proven effective therapies for this virus exists. The vaccines are deemed as a significant part of disease prevention for emerging viral diseases, since, in several cases, other therapeutic choices are limited or non�existent, or that diseases result in such an accelerated clinical worsening that the efficacy of treatments is restricted. Therefore, effective vaccines against COVID-19 are urgently required to overcome the tremendous burden of mortality and morbidity correlated with SARS-CoV-2. In this review, we will describe the latest evidence regarding outstanding vaccine approaches and the challenges for vaccine production. © 2020 Elsevier B.V.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: guanine nucleotide binding protein; M protein; severe acute respiratory syndrome coronavirus 2 vaccine; unclassified drug; viral protein; virus M protein; virus S protein; virus vaccine, antibody dependent enhancement; coronavirus disease 2019; drug efficacy; human; immunity; Middle East respiratory syndrome; nonhuman; priority journal; protein function; Review; severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; vaccine production; virus pathogenesis
Subjects: سیستم تنفسی WF
بیماریهای واگیرWC
میکروب شناسی وایمنی شناسی QW
بهداشت عمومی WA
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Sep 2020 06:26
Last Modified: 14 Sep 2020 06:26
URI: http://eprints.goums.ac.ir/id/eprint/10780

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