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Evaluation of Radiation Sensitivity in Patients with Hyper IgM Syndrome

Fekrvand, S. and Mozdarani, H. and Delavari, S. and Sohani, M. and Nazari, F. and Kiaee, F. and Bagheri, Y. and Azizi, G. and Hassanpour, G. and Mozdarani, S. and Abolhassani, H. and Aghamohammadi, A. and Yazdani, R. (2020) Evaluation of Radiation Sensitivity in Patients with Hyper IgM Syndrome. Immunological Investigations.

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Abstract

Background: HIGM syndrome is a rare form of primary immunodeficiencies characterized by normal/increased amounts of serum IgM and decreased serum levels of other switched immunoglobulin classes. Since the affected patients are continuously infected with various types of pathogens and are susceptible for cancers, diagnostic and therapeutic tests including imaging techniques are recommended for the diagnosis and treatment of these patients, which predispose them to higher accumulated doses of radiation. Given the evidence of class switching recombination machinery defect and its association with an increased rate of DNA repair, we aimed to evaluate radiation sensitivity among a group of patients diagnosed with HIGM syndrome. Methods: 19 HIGM patients (14 CD40 L and 3 AID deficiencies and 2 unsolved cases without known genetic defects) and 17 control subjects (10 healthy subjects as negative control group, 7 ataxia-telangiectasia patients as positive control group) were enrolled. G2 assay was carried out for the determination of radiosensitivity. Results: Based on radiation-induced chromosomal changes among the studied HIGM patients and their comparison with the controls, almost all (95) the patients had degrees of radiosensitivity: 6 patients with low to moderate, 1 patient with moderate, 11 patients with severe and 1 patient without radiation sensitivity. Conclusion: Today, X-ray radiation plays a very important role in diagnostic and therapeutic procedures; while increased exposure has devastating effects especially in radiosensitive patients. Considering higher sensitivity in HIGM patients, utilizing radiation-free techniques could partly avoid unnecessary and high-level exposure to radiation, thus preventing or reducing its harmful effects on the affected patients. © 2020, © 2020 Taylor & Francis Group, LLC.

Item Type: Article
Additional Information: cited By 0
Subjects: سیستم های خونی و لنفاوی WH
آسیب شناسی QZ
میکروب شناسی وایمنی شناسی QW
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 13 Jul 2020 09:02
Last Modified: 13 Jul 2020 09:02
URI: http://eprints.goums.ac.ir/id/eprint/10722

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