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Molecular and biochemical mechanisms of human iris color: A comprehensive review

Dorgaleleh, S. and Naghipoor, K. and Barahouie, A. and Dastaviz, F. and Oladnabi, M. (2020) Molecular and biochemical mechanisms of human iris color: A comprehensive review. Journal of Cellular Physiology.

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Abstract

Eye color is determined as a polymorphism and polygenic trait. Brown is the most common eye color in the world, accounting for about 79, blue eye color for about 8�10, hazel for 5, and green for 2. Rare-colored eyes include gray and red/violet. Different factors are involved in determining eye color. The two most important factors are the iris pigment and the way light is scattered from the iris. Gene expression determines the iris pigmentation and how much melanin is present in the eye, which is the number of melanin subunits that identify eye color. The genes involved in the pigmentation of single-nucleotide polymorphism (SNP) have a significant role; and even some genes are included only in the eye color through SNP. MicroRNAs also affect melanocyte synthesis, which is usually affected by the downregulation of essential genes involved in pigmentation. In this study, we assess the biochemical pathways of melanin synthesis, and the role of each gene in this pathway also has been examined in the signaling pathway that stimulates melanin synthesis. © 2020 Wiley Periodicals LLC

Item Type: Article
Additional Information: cited By 0
Subjects: QU بیوشیمی
چشم پزشکی WW
آسیب شناسی QZ
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Jun 2020 08:39
Last Modified: 10 Jun 2020 08:39
URI: http://eprints.goums.ac.ir/id/eprint/10664

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