Golestan University of Medical Sciences Repository

microRNAs involved in T-cell development, selection, activation, and hemostasis

Emamgolizadeh Gurt Tapeh, B. and Mosayyebi, B. and Samei, M. and Beyrampour Basmenj, H. and Mohammadi, A. and Alivand, M.R. and Hassanpour, P. and Solali, S. (2020) microRNAs involved in T-cell development, selection, activation, and hemostasis. Journal of Cellular Physiology.

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Abstract

MicroRNAs (miRNAs) characterized by small, noncoding RNAs have a fundamental role in the regulation of gene expression at the post-transcriptional level. Additionally, miRNAs have recently been identified as potential regulators of various genes involved in the pathogenesis of the autoimmune and inflammatory disease. So far, the interaction between miRNAs and T lymphocytes in the immune response as a new and significant topic has not been emphasized substantially. The role of miRNAs in different biological processes including apoptosis, immune checkpoints and the activation of immune cells is still unclear. Aberrant miRNA expression profile affects various aspects of T-cell function. Accordingly, in this literature review, we summarized the role of significant miRNAs in T-cell development processes. Consequently, we demonstrated precise mechanisms that candidate miRNAs interfere in Immune response mediated by different types of T cells. We believe that a good understanding of the interaction between miRNAs and immune response contributes to the new therapeutic strategies in relation to disease with an immunological origin. © 2020 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 0
Subjects: سیستم های خونی و لنفاوی WH
آسیب شناسی QZ
میکروب شناسی وایمنی شناسی QW
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 May 2020 08:18
Last Modified: 18 May 2020 08:18
URI: http://eprints.goums.ac.ir/id/eprint/10644

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