Golestan University of Medical Sciences Repository

Effect of Propolis Intake on Serum C-Reactive Protein (CRP) and Tumor Necrosis Factor-alpha (TNF-α) Levels in Adults: A Systematic Review and Meta-Analysis of Clinical Trials

Jalali, M. and Ranjbar, T. and Mosallanezhad, Z. and Mahmoodi, M. and Moosavian, S.P. and Ferns, G.A. and Jalali, R. and Sohrabi, Z. (2020) Effect of Propolis Intake on Serum C-Reactive Protein (CRP) and Tumor Necrosis Factor-alpha (TNF-α) Levels in Adults: A Systematic Review and Meta-Analysis of Clinical Trials. Complementary Therapies in Medicine, 50.

Full text not available from this repository.

Abstract

Background: Propolis is a natural Product and the antioxidant properties of Propolis appear to be principally responsible for its therapeutic effects. However, several studies have shown the positive effect of Propolis on the reduction the levels of inflammatory markers; some others have revealed non-significant impacts on them. Hence, the present systematic review and meta-analysis aimed to investigate the effects of Propolis intake on C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α). Methods: The systematic search was undertaken in scientific databases that included: PubMed, Embase, Scopus and Web of Science to find studies assessing the effects of Propolis on CRP and TNF-α up to December 2019. Standardized mean difference (SMD) and 95 confidence intervals (CI) were pooled using a random-effects model. Potential publication bias was tested using Egger's test. Results: Six studies comprising 406 participants were included in the meta-analysis. Compared to controls, Propolis intake significantly reduced serum TNF-α (SMD = �0.48, 95 CI = �0.69, �0.26, P < 0.0001, I2 = 66.9 %) and CRP (SMD = �0.38, 95 % CI = �0.68, �0.07, P = 0.01, I2 = 44.4 %) levels. No evidence of publication bias was found in the meta-analyses. Conclusion: The present study concluded in the statistically and clinically reduction of serum CRP and TNF-α levels following Propolis intake. © 2020 Elsevier Ltd

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: C reactive protein; propolis; tumor necrosis factor, adult; diet supplementation; human; meta analysis; outcome assessment; protein blood level; publication bias; Review; systematic review; treatment duration
Subjects: QU بیوشیمی
آسیب شناسی QZ
آسیب شناسی بالینی QY
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 16 May 2020 08:18
Last Modified: 16 May 2020 08:18
URI: http://eprints.goums.ac.ir/id/eprint/10627

Actions (login required)

View Item View Item