Golestan University of Medical Sciences Repository

Diagnostic approach to the patients with suspected primary immunodeficiency

Tavakol, M. and Jamee, M. and Azizi, G. and Sadri, H. and Bagheri, Y. and Zaki-Dizaji, M. and Mahdavi, F.S. and Jadidi-Niaragh, F. and Tajfirooz, S. and Kamali, A.N. and Aghamahdi, F. and Noorian, S. and Kojidi, H.T. and Mosavian, M. and Matani, R. and Dolatshahi, E. and Porrostami, K. and Elahimehr, N. and Fatemi-Abhari, M. and Sharifi, L. and Arjmand, R. and Haghi, S. and Zainaldain, H. and Yazdani, R. and Shaghaghi, M. and Abolhassani, H. and Aghamohammadi, A. (2020) Diagnostic approach to the patients with suspected primary immunodeficiency. Endocrine, Metabolic and Immune Disorders - Drug Targets, 20 (2). pp. 157-171.

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Abstract

Background and Objective: Primary immunodeficiency diseases (PIDs) are a group of more than 350 disorders affecting distinct components of the innate and adaptive immune systems. In this review, the classic and advanced stepwise approach towards the diagnosis of PIDs are simplified and explained in detail. Results: Susceptibility to recurrent infections is the main hallmark of almost all PIDs. However, non-infectious complications attributable to immune dysregulation presenting with lymphoproliferative and/or autoimmune disorders are not uncommon. Moreover, PIDs could be associated with misleading presentations including allergic manifestations, enteropathies, and malignancies. Conclusion: Timely diagnosis is the most essential element in improving outcome and reducing the morbidity and mortality in PIDs. This wouldn�t be possible unless the physicians keep the diagnosis of PID in mind and be sufficiently aware of the approach to these patients. © 2020 Bentham Science Publishers.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: immunoglobulin A; immunoglobulin E; immunoglobulin G, autoimmune disease; blood cell count; chromosome analysis; complement hemolysis test; copy number variation; diagnostic procedure; enteropathy; enzyme linked immunosorbent assay; flow cytometry; fluorescence in situ hybridization; genetic screening; granulomatosis; high throughput sequencing; human; immune deficiency; immune dysregulation; immunoglobulin blood level; lymphocyte; lymphoproliferative disease; microarray analysis; neutrophil count; pneumonia; recurrent infection; regulatory T lymphocyte; Review; risk factor; Sanger sequencing; severe combined immunodeficiency; single nucleotide polymorphism; vaccination; whole exome sequencing; Wiskott Aldrich syndrome
Subjects: پزشکی عملیWB
میکروب شناسی وایمنی شناسی QW
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 21 Apr 2020 06:12
Last Modified: 21 Apr 2020 06:12
URI: http://eprints.goums.ac.ir/id/eprint/10574

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