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Potential drugs used in the antibody�drug conjugate (ADC) architecture for cancer therapy

Yaghoubi, S. and Karimi, M.H. and Lotfinia, M. and Gharibi, T. and Mahi-Birjand, M. and Kavi, E. and Hosseini, F. and Sineh Sepehr, K. and Khatami, M. and Bagheri, N. and Abdollahpour-Alitappeh, M. (2020) Potential drugs used in the antibody�drug conjugate (ADC) architecture for cancer therapy. Journal of Cellular Physiology, 235 (1). pp. 31-64.

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Abstract

Cytotoxic small-molecule drugs have a major influence on the fate of antibody�drug conjugates (ADCs). An ideal cytotoxic agent should be highly potent, remain stable while linked to ADCs, kill the targeted tumor cell upon internalization and release from the ADCs, and maintain its activity in multidrug-resistant tumor cells. Lessons learned from successful and failed experiences in ADC development resulted in remarkable progress in the discovery and development of novel highly potent small molecules. A better understanding of such small-molecule drugs is important for development of effective ADCs. The present review discusses requirements making a payload appropriate for antitumor ADCs and focuses on the main characteristics of commonly-used cytotoxic payloads that showed acceptable results in clinical trials. In addition, the present study represents emerging trends and recent advances of payloads used in ADCs currently under clinical trials. © 2019 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: antibody drug conjugate; antineoplastic agent; auristatin; calicheamicin; camptothecin derivative; cytotoxic agent; DNA; doxorubicin; duocarmycin; maytansine derivative; nucleotidyltransferase inhibitor; protein bcl xl; pyrrolobenzodiazepine; RNA polymerase; tubulysin; unclassified drug, cancer therapy; conjugate; cytotoxicity; DNA damage; drug potency; drug structure; drug targeting; history of medicine; human; malignant neoplasm; market; microtubule; nonhuman; pipeline; priority journal; Review; spliceosome
Subjects: QU بیوشیمی
فارماکولوژی QV
> دانشکده داروسازی > فارماکولوژی QV

مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 09 Mar 2020 11:04
Last Modified: 09 Mar 2020 11:04
URI: http://eprints.goums.ac.ir/id/eprint/10563

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