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Protective effects of pharmacological agents against aminoglycoside-induced nephrotoxicity: A systematic review

Mahi-Birjand, M. and Yaghoubi, S. and Abdollahpour-Alitappeh, M. and Keshtkaran, Z. and Bagheri, N. and Pirouzi, A. and Khatami, M. and Sineh Sepehr, K. and Peymani, P. and Karimzadeh, I. (2020) Protective effects of pharmacological agents against aminoglycoside-induced nephrotoxicity: A systematic review. Expert Opinion on Drug Safety.

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Abstract

Introduction: Aminoglycosides have been long used for antibacterial treatment and are still commonly used in clinical practice. Despite their extensive application and positive effects, drug-related toxicity is considered as the main obstacle for aminoglycosides. Aminoglycosides induce nephrotoxicity through the endocytosis and accumulation of the antibiotics in the epithelial cells of proximal tubule. Most importantly, however, a number of pharmacological agents were demonstrated to have protective activities against nephrotoxicity in experimental animals. Areas covered: In the present systematic review, the authors provide and discuss the mechanisms and epidemiological features of aminoglycoside-induced nephrotoxicity, and focus mainly on recent discoveries and key features of pharmacological interventions. In total, 39 articles were included in this review. Expert opinion: The majority of studies investigated gentamicin-induced nephrotoxicity in animal models. Antioxidants, chemicals, synthetic drugs, hormones, vitamins, and minerals showed potential values to prevent gentamicin-induced nephrotoxicity. Indicators used to evaluate the effectiveness of nephroprotection included antioxidative indexes, inflammatory responses, and apoptotic markers. Among the nephroprotective agents studied, herbs and natural antioxidant agents showed excellent potential to provide a protective strategy against gentamicin-induced nephrotoxicity. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: cited By 0
Subjects: QU بیوشیمی
فارماکولوژی QV
> دانشکده داروسازی > فارماکولوژی QV

مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Apr 2020 04:14
Last Modified: 14 Apr 2020 04:14
URI: http://eprints.goums.ac.ir/id/eprint/10561

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