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Gorgan (Iran) population HLA genetics and anthropology

Arnaiz-Villena, A. and Juarez, I. and Joshghan, H. and Lopez-Nares, A. and Rey, D. and Callado, A. and H-Sevilla, A. and Rashidi, F. and Nikbin, B. and Amirzargar, A. (2020) Gorgan (Iran) population HLA genetics and anthropology. Human Immunology, 81 (1). pp. 10-11.

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Abstract

Gorgan (Iran) have been studied for HLA-A, -B, -C, -DRB1 and -DQB1 genes for the first time. They are Turkmen and originated in East Asia around Altai Mts; they originally spoke a Turk language classified within the Turkish-Oguz group. Peripheral blood samples were collected from Gorgan City (Iran) and HLA typed by standard methodology. HLA allele frequencies were compared with 7984 chromosomes of other World populations and it was shown existence of admixture of Siberian and Mediterranean HLA characters in this population, probably due to longlasting contact with Persians. Three new HLA extended haplotypes were found: A*01:01-B*35:01-DRB1*03:01-DQB1*02:01, A*30:01-B*13:01-DRB1*15:01-DQB1*02:01 and A*31:01-B*35:01-DRB1*15:01-DQB1*03:01. Gorgan (Iran) were most close to Chuvashians (Noth Caspian Sea, Russia) and Siberians, like Tuvinians, Mansi and Buryats in Neighbour Joining and Vista analyses. It is established a relationship of this population with Kurgan (Gorgan, Iran) archaeological mounds culture. However, their kinship with Scythians (2nd century BC) and Sarmatians (4th century AD) is obscure although both of them spoke a Persian language. © 2019 American Society for Histocompatibility and Immunogenetics

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: HLA A antigen; HLA DQB1 antigen; HLA DRB1 antigen, Article; blood sampling; Buryat (people); Caspian Sea; chromosome; gene frequency; haplotype; HLA system; human; immunogenetics; Iran; Mansi (people); medical anthropology; Persian (people); priority journal
Subjects: QS آناتومی انسان
QTفیزیولوژی
آسیب شناسی QZ
بهداشت عمومی WA
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Apr 2020 05:28
Last Modified: 14 Apr 2020 05:28
URI: http://eprints.goums.ac.ir/id/eprint/10542

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