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Effects of dietary myrcene administration on antioxidant gene responses in common carp (Cyprinus carpio), exposed to copper sulphate

Khalili, M. and Attar, M. and Amirlatifi, R. and Maleki, Z.N. and Hoseini, S.M. (2020) Effects of dietary myrcene administration on antioxidant gene responses in common carp (Cyprinus carpio), exposed to copper sulphate. Aquaculture Research.

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Abstract

In the present study, common carp (Cyprinus carpio) were fed with diet supplemented with 0 (M0) or 0.5 (M0.5) myrcene for 6 week and exposed to ambient copper (0.2 mg/L) for further 2 weeks. Gene expressions of superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), glutathione reductase (gr) and glutathione S-transferase (gst) were assayed in the fish brain and kidney, and thiobarbituric reactive substance (TBARS) levels were determined in blood plasma. The results showed that there was no significant difference in TBARS levels between the M0 and M0.5 treatments, before the copper exposure; however, the M0 had significantly higher TBARS levels compared to the M0.5, after the copper exposure. The antioxidant genes showed different patterns in the fish brain and kidney. The genes were up-regulated in the fish brain by dietary myrcene and copper exposure. However, in the fish kidney, the M0.5 treatment showed no change in sod, cat, gpx before and after the copper exposure. The results suggest that myrcene is capable to induce antioxidant enzymes that prepare the fish for a further oxidative condition (i.e. copper exposure). Dietary myrcene at 0.5 level is suggested for common carp before treatment with copper sulphate. © 2020 John Wiley & Sons Ltd

Item Type: Article
Additional Information: cited By 0
Subjects: QU بیوشیمی
فارماکولوژی QV
> دانشکده داروسازی > فارماکولوژی QV

مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Apr 2020 05:37
Last Modified: 14 Apr 2020 05:37
URI: http://eprints.goums.ac.ir/id/eprint/10539

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