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Levetiracetam for prophylactic treatment of pediatric migraine: A randomized double-blind placebo-controlled trial

Montazerlotfelahi, H. and Amanat, M. and Tavasoli, A.R. and Agah, E. and Zamani, G.R. and Sander, J.W. and Badv, R.S. and Mohammadi, M. and Dehghani, M. and Heidari, M. and Hosseini, S.A. and Salehi, M. and Ashrafi, M.R. (2019) Levetiracetam for prophylactic treatment of pediatric migraine: A randomized double-blind placebo-controlled trial. Cephalalgia, 39 (12). pp. 1509-1517.

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Abstract

Introduction: Few drugs are available for migraine prophylaxis in children. Levetiracetam is a broad-spectrum anti-seizure drug that has been suggested to be effective in reducing adult migraine episodes. We assessed the safety and efficacy of levetiracetam in the prevention of pediatric migraine. Methods: A randomized double-blind placebo-controlled trial was performed. Eligible participants were aged 4�17 years old with at least four migrainous episodes monthly or had severe disabling or intolerable episodes. Primary endpoints were the mean changes in monthly frequency and intensity of headaches from the baseline phase to the last month of the double-blind phase. Safety endpoint was the adverse effects reported. Results: Sixty-one participants (31 taking levetiracetam and 30 taking placebo) completed the study. All had a significant reduction in frequency and intensity of episodes that was significantly greater in the levetiracetam arm. Sixty eight percent of individuals in the treatment group reported more than 50 reduction of episodes at the end of the trial compared with 30 in the placebo group (p-value: 0.007). Irritability, day-time sedation, and mild tic were reported. Conclusion: Levetiracetam may be useful in migraine prevention and may decrease migraine episodes and severity. Trial Registration: The study is prospectively registered with Iranian Registry of Clinical Trials; IRCT.ir, number IRCT2017021632603N1. © International Headache Society 2019.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: levetiracetam; placebo, adolescent; Article; child; clinical article; controlled study; disease severity; double blind procedure; drug effect; drug efficacy; drug safety; female; follow up; human; irritability; male; migraine; randomized controlled trial; sedation; side effect; tic; treatment outcome
Subjects: سیستم عصبی WL
بیماریهای کودکانWS
QU بیوشیمی
فارماکولوژی QV
> دانشکده داروسازی > فارماکولوژی QV

مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 31 Dec 2019 10:35
Last Modified: 31 Dec 2019 10:35
URI: http://eprints.goums.ac.ir/id/eprint/10487

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