Golestan University of Medical Sciences Repository

Association of interleukin 13/+110 gene polymorphism with hepatitis B virus infection in golestan province, northern Iran

Zangi, M. and Bakhshandeh, A. and Mehrpouya, M. and Shahbazi, M. (2019) Association of interleukin 13/+110 gene polymorphism with hepatitis B virus infection in golestan province, northern Iran. Jundishapur Journal of Microbiology, 12 (3).

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Abstract

Background: The most common primary cause of liver cancer is hepatocellular carcinoma (HCC). Cytokines as mediators have significant roles in immune and inflammatory responses. Interleukin-13 (IL-13) is a potent pleiotropic cytokine. Objectives: The aim of this study was to evaluate the association of IL-13/+110 gene polymorphism in patients with chronic hepatitis B virus (HBV), one of the most important factors that lead to the development of HCC. Methods: DNA was extracted from peripheral blood cells of all 585 participants including 302 unrelated Hepatitis B surface antigen (HBS-Ag) positives and 283 healthy matched groups. The IL-13 gene polymorphism (+ 110 A or G) was genotyped by SSP-PCR method and then genotype frequencies were checked by using the Pearson�s chi-square test and/or Fisher exact test. Results: The frequencies of A/G genotype (CI = 1.18 - 2.34, OR = 1.66, P = 0.004) and A/A genotype (CI = 0.95 - 3.53, OR = 1.84, P = 0.071) were higher in the patients. Also, the frequency of A allele was remarkably higher in the HBV patients than control group (CI = 1.09 - 1.79, OR = 1.84, P = 0.071). Conclusions: High frequency of A allele in patients rather than control group suggested that A allele probably plays a role in augmenting susceptibility to HBV infection risk and high frequency of G allele in controls suggested this allele has a protective role in this disease. © 2019, Kowsar Medical Publishing Company. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: cytokine; hepatitis B surface antigen; interleukin 110; interleukin 13; unclassified drug, Article; case control study; controlled study; disease association; DNA extraction; DNA polymorphism; female; gene frequency; genotype; health; hepatitis B; Hepatitis B virus; human; Iran; major clinical study; male; polymerase chain reaction
Subjects: سیستم گوارشی WI
بیماریهای واگیرWC
آسیب شناسی QZ
میکروب شناسی وایمنی شناسی QW
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 25 Dec 2019 10:07
Last Modified: 25 Dec 2019 10:07
URI: http://eprints.goums.ac.ir/id/eprint/10483

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